New services available. After re-optimization, Human ROR-alpha is once again available for research services. Go to the Nuclear Receptor Assays page to learn more.
New services available. Rat and mouse glucocorticoid receptor (GR) assays are now available. Go to the Nuclear Receptor Assays page to learn more.
New services available. Human RXRbeta and RXRgamma assays are now available. We now offer all three members of the RXR family! Go to the Nuclear Receptor Assays page to learn more.
See the list of preferred and alternate reference compounds for our nuclear receptor reporter assays, here.
A page with example agonist and antagonist dose-response data has been created, here
Click here to see a new depiction of the formats of our nuclear receptor reporter assays
Please note that we have a new sample submission form. Please click here (or use the link on the left).
In addition to being a provider of convenient, ready-to-use Nuclear Receptor kits, INDIGO Biosciences, Inc. also provides Contract Research Services. If you do not have the equipment or expertise to utilize our kits, we would be happy to run the assays in our laboratories and send you the results. We also provide services that currently are not part of our product portfolio, including non-human nuclear receptor assays, gene expression and custom assay development. Our research services team has all the expertise necessary to examine your compounds for on-target as well as off-target effects.
Contact us to find out more.
Nuclear Receptor Reporter Assays
INDIGO utilizes cell-based, reporter assays to examine the effects of chemicals, drugs and nutrients on nuclear receptor activity. We offer over 50 different assays including human, rat and mouse orthologs of several nuclear receptors including the PPARs, LXRs, RXRα, GR and CAR.
Nuclear Receptor Reporter Panels
INDIGO offers significant discounts on screens that include more than five receptors from our portfolio. Choose from our pre-determined panels (Toxicology, Metabolic Diseases, Endocrinology) or pick your own grouping of receptors.
Custom Assay Development
Having difficulty developing an assay? Interested in an animal model but can't find the appropriate tools? INDIGO has vast experience cloning nuclear receptors from a variety of species and developing robust whole cell-based assays. We can develop the assay under a non-propriety agreement for your use in-house or for screening in our labs.
INDIGO's offers a variety of services meant to examine the down-stream effects of nuclear receptor activation. These "Functional Assays" include analysis of gene expression and cell culture-based model systems for examination of adipogenesis or reverse cholesterol transport.
Allow our experienced and highly-qualified staff give you the data you need, quickly and without using your resources. All data is confidential (see Standard Terms and Agreement) and in most cases INDIGO can provide detailed information rapidly.