Benzyl derivative compounds having peroxisome proliferator-activated receptor α (PPARα) agonistic activity, compositions containing such compounds, and methods of their use in enhancing PPARα activity for treating diseases and/or conditions involving inflammation and/or angiogenesis, particularly ocular diseases and/or conditions such as but not limited to retinal inflammation, retinal neovascularization, retinal vascular leakage, retinopathy of prematurity, diabetic retinopathy, age-related macular degeneration, and diabetic macular edema are disclosed.
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Date of publication: 28 January 2021; United States Patent Application 20210024469
Inventor Information: Duerfeldt, Adam (Norman, OK, US), Ma, Jian-xing (Edmond, OK, US), Dou, Xiaozheng (Norman, OK, US), Nath, Dinesh (Meerut, IN), Shin, Young-hwa (Oklahoma City, OK, US)
Assignee: The Board of Regents of the University of Oklahoma (Norman, OK, US)