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Comprehensive Examination of Induction of Drug Metabolizing Enzymes in Human upcyte® Hepatocytes

View Full Size Research conducted by: Samar W. Maalouf (1); John P. Vanden Heuvel (1,2); Bruce Sherf (1); &Zahidur R. Abedin (3) (1) INDIGO Biosciences, Inc., 1981 Pine Hall Road, State College, PA, USA (2) Department of Veterinary Medicine and Biomedical Sciences, 122 ASI, Penn State University, University Park, PA, USA (3) PrimBio Research Institute,Read More

Regulation of Steatosis in upcyte® Hepatocytes by Nuclear Receptor Agonists

View Full Size Research conducted by: Bruce Sherf (1); Samar W. Maalouf (1); Kaarthik John (1); Zahidur R. Abedin (1); & John P. Vanden Heuvel (1,3) (1) INDIGO Biosciences, Inc., 1981 Pine Hall Road, State College, PA, USA (2) PrimBio Research Institute, LLC, 665 Stockton Drive, STE 2001, Exton,  PA, USA (Website) (3) Department ofRead More

Examination of Drug-induced Liver Injury in upcyte® Hepatocytes

View Full Size Research conducted by: John P. Vanden Heuvel (1,2); Samar Maalouf (1); Megan V. Granda (2); & Bruce Sherf (1) (1) INDIGO Biosciences, Inc., 1981 Pine Hall Road, State College, PA, USA (2) Department of Veterinary Medicine and Biomedical Sciences, 122 ASI, Penn State University, University Park, PA 16802, USA Date of Publication:Read More

Detection of cytokeratin 18 in proliferating, primary-like upcyte® hepatocytes to predict drug-induced hepatotoxicity

View Full Size Research conducted by: Wiebe Schaefer (1), Astrid Noerenberg (1), Adrian Kling (2), Giannella Coghlan (2), Nils Runge (1), & Timo Johannssen (1) (1) upcyte technologies GmbH, Osterfeldstr. 12-14, 22529 Hamburg, Germany (2) VLVbio AB, Hästholmsvägen 32, 13130 Nacka, Sweden Date of Publication: 2017

Use of upcyte® hepatocytes as a steatosis model on a multi-organ chip

View Full Size Research conducted by: S. Bauer (2), C. Magauer (2), I. Maschmeyer (2), C. Drewell (1), A. Lorenz (2), N. Runge (3), T. Johannssen (3), U. Marx (2), & A. Noerenberg (3) (1) Technische Universität Berlin, Medizinische Biotechnologie (2) TissUse, Berlin, Germany (3) upcyte technologies GmbH, Osterfeldstr. 12-14, D-22529 Hamburg, Germany Date of Publication: 2017

Profiling Drug Activity of Human and Ortholog Xenobiotic-Sensing Receptors: PXR, CAR, AhR, and FXR

View Full Size Research conducted by: Koji Toyokawa (1), Ewa Maddox (1), Jack Vanden Huevel (1,2), & Bruce Sherf (1) (1) INDIGO Biosciences, Inc., 1981 Pine Hall Rd, State College, PA, USA (2) Center for Molecular Toxicology and Carcinogenesis, 325 Life Sciences Building, Penn State University, University Park, PA 16802, USA Date of Publication: 2017

Validating the Gene Expression of Clinically Relevant CYP450 Enzymes and Transporters in Human upcyte® Hepatocytes to Develop an In Vitro Predictive Tool for DDI

View Full Size Research conducted by: Samaar Maalouf (1), Bruce Sherf(1), & Jack Vanden Huevel (1,2) (1) INDIGO Biosciences, Inc., 1981 Pine Hall Road, State College, PA, USA (2) Center for Molecular Toxicology and Carcinogenesis, 325 Life Sciences Building, Penn State University, University Park, PA 16802, USA Date of publication: 2017

Inhibition of Mitochondrial Gene Expression by Nucleoside Analogues and Delayed Mitochondrial Dysfunction

View Full Size Research conducted by: Midhun Korrapati(1), Koji Toyokawa (1), Bruce Sherf (1), & Jack Vanden Huevel (1,2) (1) INDIGO Biosciences, Inc., 1981 Pine Hall Rd, State College, PA, USA (2) Center for Molecular Toxicology and Carcinogenesis, 325 Life Sciences Building, Penn State University, University Park, PA 16802, USA Date of publication: March 2016