Nuclear Receptor & In Vitro Toxicology Solutions™

Get all the latest news from INDIGO

  • This field is for validation purposes and should be left unchanged.

  • ABOUT
    • About INDIGO
    • Why INDIGO
    • Key Personnel
      • Board of Directors & Advisors
      • Management
    • Employment
    • INDIGO Press Releases
    • INDIGO in the News
  • ASSAYS
    • By Receptor
    • By Disease State
      • Overview
      • Anemia & Kidney Disease
      • Autoimmune Disease & Inflammation
      • Cancer
      • Cardiovascular Disease
      • Diabetes
      • Endocrinology
      • NAFLD/NASH
      • Obesity
    • Toxicology Solutions
      • In Vitro Toxicology Platform
      • Gene Expression
      • MDR1 / Human P-Glycoprotein
      • Discovery Toxicology
      • Environmental Monitoring
    • INDIGlo Luciferase Detection Reagent
    • Live Cell Multiplex
    • Ortholog Assays
    • Custom Assay Development
  • TECHNOLOGY
    • Nuclear Receptor Overview
    • Assay Kit Platform & Formats
    • Nuclear Receptor Profiling & Panels
    • Environmental Testing Solutions
    • Growth Factor Receptors
    • upcyte® Hepatocytes
    • FAQ
  • RESOURCES
    • Technical Manuals
    • Safety Data Sheets
    • Scientific Whitepapers from INDIGO
    • Scientific Posters
    • New Research Publications
    • Nuclear Receptor Resource
  • CONTACT US
    • Contact INDIGO
    • Request a Quote
    • Request Information
    • Distributors
    • Terms & Conditions
      • Product Policies
      • Limited Use Disclosures
  • BLOG

Nuclear Receptor & In Vitro Toxicology Solutions™

Search site...

± α β γ δ Δ ε ζ κ ω ö ® ™ µ

  • ABOUT
    • About INDIGO
    • Why INDIGO
    • Key Personnel
      • Board of Directors & Advisors
      • Management
    • Employment
    • INDIGO Press Releases
    • INDIGO in the News
  • ASSAYS
    • By Receptor
    • By Disease State
      • Overview
      • Anemia & Kidney Disease
      • Autoimmune Disease & Inflammation
      • Cancer
      • Cardiovascular Disease
      • Diabetes
      • Endocrinology
      • NAFLD/NASH
      • Obesity
    • Toxicology Solutions
      • In Vitro Toxicology Platform
      • Gene Expression
      • MDR1 / Human P-Glycoprotein
      • Discovery Toxicology
      • Environmental Monitoring
    • INDIGlo Luciferase Detection Reagent
    • Live Cell Multiplex
    • Ortholog Assays
    • Custom Assay Development
  • TECHNOLOGY
    • Nuclear Receptor Overview
    • Assay Kit Platform & Formats
    • Nuclear Receptor Profiling & Panels
    • Environmental Testing Solutions
    • Growth Factor Receptors
    • upcyte® Hepatocytes
    • FAQ
  • RESOURCES
    • Technical Manuals
    • Safety Data Sheets
    • Scientific Whitepapers from INDIGO
    • Scientific Posters
    • New Research Publications
    • Nuclear Receptor Resource
  • CONTACT US
    • Contact INDIGO
    • Request a Quote
    • Request Information
    • Distributors
    • Terms & Conditions
      • Product Policies
      • Limited Use Disclosures
  • BLOG

Nuclear Receptor Profiling

INTRODUCTION Nuclear Receptors act as transcription factors that mediate the effects of certain hormones, drugs, and other xenobiotics by modulating the expression of specific genes involved in many cellular functions such as development, reproduction, and metabolism. Conserved functional domains of nuclear receptors such as the DNA-binding domain (DBD), ligand-binding domain (LBD), N- and C-terminal transcriptionalRead More

Filed Under: Whitepapers Tagged With: Nuclear Receptor profiling

Xenobiotic, Bile Acid, and Cholesterol Transporters

INTRODUCTION Uptake and efflux transporters determine plasma and tissue concentrations of a broad variety of drugs, nutrients, and xenobiotics (1-3). The liver is the primary organ for the metabolic degradation of xenobiotics. Transmembrane transport proteins from the ATP binding cassette (ABC) and the solute carrier (SLC) families mediate the uptake and efflux of endogenous compounds,Read More

Filed Under: Whitepapers

Species Differences in Pregnane X Receptor Activation: Examination of common laboratory animal species

INTRODUCTION Nuclear receptors (NRs) are ligand-dependent transcription factors found in many species that regulate the expression of important target genes involved in a spectrum of developmental and physiological processes. In addition to ligand binding, the transcriptional activities of NRs are also modulated through a range of protein-protein interactions with coregulatory proteins, either with coactivator orRead More

Filed Under: Whitepapers Tagged With: ortholog, PXR

Drug-Nutrient Interactions and Nuclear Receptors

INTRODUCTION There are several clinically relevant instances of a food or dietary supplement altering the activity of a pharmaceutical agent. For example, St. John’s Wort (Hypericum perforatum), a popular herbal antidepressant, affects pharmacokinetic actions of HIV protease inhibitors, antidepressants, antihypertensives, and oral contraceptives. Drug-nutrient interaction (DNI) represents a relationship between a medication and one orRead More

Filed Under: Whitepapers

Gene Expression: Nuclear Receptors

INTRODUCTION There are four main classes of receptors, Ion channels, G-protein coupled (GPCR), receptor tyrosine kinase and soluble (also called intracellular) receptors. The first three have ligands that are mainly present in the extracellular space (water soluble ligands). The binding of ligand causes a change in the shape/function of the protein that generates a signalRead More

Filed Under: Whitepapers Tagged With: AhR, AR, ERa, ERb, gene expression, GR, PGR, RAR, TRa, TRb, VDR

Nuclear Receptors & Endocrine / Metabolic Disruption

INTRODUCTION There are many important environmental chemicals that are of concern due to their ability to affect the endocrine system, so-called endocrine disrupting chemicals (EDCs). Compounds that cause endocrine disruption may do so by altering drug and xenobiotic metabolic processes; hence, a subgroup of EDCs may also be considered “metabolic disruptors” as well. In thisRead More

Filed Under: Whitepapers

INDIGO Biosciences - The right partner for all your discovery and toxicology needs.
Search site...
Click to Insert Symbols in Search

α β γ δ Δ ε ζ κ ® ™ µ

Want More Information?

Simply fill out this form and we'll be in touch!

Resource Quick Links

  • Technical Manuals & Product Listing
  • Safety Data Sheets
  • Sample Study Report
  • Study Work Order Form

3006 Research Drive, Suite A1, State College, PA, USA 16801

+1 (814) 234-1919

  • Home
  • Products
  • Request a Quote
  • FAQ

© 2022 INDIGO Biosciences, Inc. All Rights Reserved