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Eating competence is related to PPARβ/d and PGC-1a genotypes

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 ABSTRACT

PPARa L162A, PPARg 12A, PPARβ/d rs226766 , and PGC-1a G482S genotype distributions were compared with TFEQ-R18 and ecSI scores; responses were gender-specific and paralleled published values. Results confirmed less emotional eating (EE) (P<.001), cognitive restraint (CR) (P<.001) and uncontrolled eating (UE) (P=.1) with EC (ecSI score >= 32). Subjects in the lowest ecSI tertile had significantly more CR (P<.001), EE (P<.001), and UE (P=.007).

The homozygous G/G PPARβ/d genotype tended (P=.06) toward less UE; females with the homozygous G/G PPARβ/ genotype tended (P=.1) toward less CR than males. Homozygous A/A PPARg genotype tended (P=.08) toward less CR and significantly more UE (P=.04). Students of homozygous S/S PGC-1 genotype (n=35) tended not to be eating competent (P=.05) and to be in the lowest ecSI tertile (P=.14). The PPARβ/d genotype and gender interaction was significant (P=.04) with higher ecSI scores for males (35.3 ± 5.8 vs. 30.8± 4.9) who were homozygous G/G. These data support the hypothesis of a link between EC and PPARβ/d and PGC-1a genotypes.

Funded by NRI, USDA #2005-35215-154121541.

To read the full article click HERE.

Date of publication: 17 March 2011

Author information: Barbara A Lohse (1); Jack Vanden Heuvel (2); Jodi Stotts Krall (3); Jill Patterson (1); Kendra Kattelmann (4); Adrienne A White (5); & Geoffrey Greene (6)

(1) Nutritional Sciences
(2) Molecular Toxicology, The Pennsylvania State University, University Park, PA
(3) University of Pittsburgh Medical Center, Pittsburgh, PA
(4) Health and Nutritional Sciences, South Dakota State University, Brookings, SD
(5) Food Science and Human Nutrition, University of Maine, Orono, ME
(6) Nutrition and Food Sciences, University of Rhode Island, Kingston, RI

 

Filed Under: New Publications Tagged With: PPAR, PPARβ

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