There are many important environmental chemicals that are of concern due to their ability to affect the endocrine system, so-called endocrine disrupting chemicals (EDCs). Compounds that cause endocrine disruption may do so by altering drug and xenobiotic metabolic processes; hence, a subgroup of EDCs may also be considered “metabolic disruptors” as well. In this review,
we will discuss some important EDCs and their mechanism of action, in particular focusing on their interaction of nuclear receptors (NRs). Much of this information comes from recent review articles on the subject (1-6). Endocrine disruptors are exogenous compounds with the potential to disturb hormonal regulation and the normal endocrine system, consequently affecting health and reproduction in animals and humans.
Date of publication: 2015
Author: Jack Vanden Heuvel, PhD; INDIGO Biosciences, Inc.