Mouse Liver X Receptor Beta (mLXRβ; nr1h2)
Mouse Liver X Receptor Beta Assay Services
The primary application of INDIGO’s cell-based nuclear receptor assays are to quantitatively assess the bioactivity of a test compound as an agonist (activator) or antagonist (inhibition of an agonist response) of a given receptor. Service assays include a positive control reference compound and ‘vehicle’ control for every experiment. A formal study report and all data files are provided to the client upon completion of the study. To receive a quote for your proposed study, complete & submit the online “Request a Quote” form or contact an INDIGO Customer Service Representative to discuss your desired study parameters.
Service Assays: Human, Rat, Mouse
Mouse Liver X Receptor Beta Assay Background
Liver X receptor β (LXRβ) is a member of the nuclear receptor family of transcription factors. LXRβ is encoded by the NR1H2 gene (nuclear receptor subfamily 1, group H, member 2). The Liver X receptors (LXRs) were originally identified as orphan members of the nuclear receptor superfamily because their ligands were unknown. Like other receptors in the family, LXRs heterodimerize with retinoid X receptor and bind to specific response elements (LXREs) characterized by direct repeats separated by 4 nucleotides.
For more information on LXRβ, visit the Nuclear Receptor Resource.
Mouse Liver X Receptor Beta Assay Research Areas
Diabetes; Dyslipidemia; Artherosclerosis; CNS, Circadian & Basal Metabolism; Metabolic Disease; NASH/NAFLD