Rat Liver X Receptor Beta (rLXRβ; nr1h2)
| Product Family | Product Number | Product Description | Technical Manual |
| R0030 rLXRβ (NR1H2) |
R00301-32 | Rat LXRβ Reporter Assay System, 3 x 32 assays in 96-well format | |
| R00301 | Rat LXRβ Reporter Assay System, 1 x 96-well format assays | Technical Manual |
Rat Liver X Receptor Beta Assay Kit 
This Rat Liver X Receptor Beta (rLXRβ) assay kit is an all-inclusive firefly luciferase reporter assay system that includes, in addition to rLXRβ Reporter Cells, two optimized media for use during cell culture and (optionally) in diluting the test samples, a reference agonist, Luciferase Detection Reagent, a cell culture-ready assay plate, and a detailed protocol.
rLXRβ Reporter Cells are prepared using INDIGO’s proprietary CryoMite™ process. This cryo-preservation method yields high cell viability post-thaw, and provides the convenience of immediately dispensing healthy, division-competent reporter cells into assay plates. There is no need for intermediate spin-and-wash steps, viability determinations, or cell titer adjustments.
INDIGO’s rLXRb assay kits feature a luciferase detection reagent specially formulated to provide stable light emission between 5 and 90+ minutes after initiating the luciferase reaction. Incorporating a 5-minute reaction-rest period ensures that light emission profiles attain maximal stability, thereby allowing assay plates to be processed in batch. By doing so, the signal output from all sample wells, from one plate to the next, may be directly compared within an experimental set.
INDIGO's rLXRb assay kits are offered in different assay formats to accommodate researchers’ needs: 3 x 32, 1 x 96, and 1 x 384 assay formats for screening small numbers of test compounds, as well as custom bulk reagents for HTS applications.
Bulk assay reagents can be custom manufactured to accommodate any scale of HTS. Please inquire.
LXRb assay kit also available in: Mouse, Human
Rat Liver X Receptor Beta Assay Services
INDIGO is a leading provider of cell-based reporter assay solutions, recognized for our focus on providing a superior combination of expertise, service, and support to organizations, ranging from pharmaceutical companies and biotechs to university labs and CROs. Lab directors across the globe leverage our industry-leading platforms, knowledgeable people, and proprietary science at every stage of discovery.
Committed to accelerating the discovery process for you, our team goes the extra mile by offering complimentary study consultation and design. Service assays include a positive control reference compound and ‘vehicle’ control for every experiment. At the completion of the study a formal study report including helpful graphics, summaries, and insights, as well as all data files are provided to the client. Our scientists are also available to provide a comprehensive review of the results with you once your service study is complete. As objective experts focused on your success, it is our duty to ensure the results we provide inform assured next steps.
To receive a quote for your proposed study, complete & submit the online “Request a Quote” form or contact an INDIGO Customer Service Representative to discuss your desired study parameters.
Service Assays: Human, Rat, Mouse
Rat Liver X Receptor Beta Assay Background
Liver X receptor β (LXRβ) is a member of the nuclear receptor family of transcription factors. LXRβ is encoded by the NR1H2 gene (nuclear receptor subfamily 1, group H, member 2). The Liver X receptors (LXRs) were originally identified as orphan members of the nuclear receptor superfamily because their ligands were unknown. Like other receptors in the family, LXRs heterodimerize with retinoid X receptor and bind to specific response elements (LXREs) characterized by direct repeats separated by 4 nucleotides.
For more information on LXRβ, visit the Nuclear Receptor Resource.
Rat Liver X Receptor Beta Assay Research Areas
Diabetes; Dyslipidemia; Artherosclerosis; CNS, Circadian & Basal Metabolism; Metabolic Disease; NASH/NAFLD