INDIGO Blog

View our most recent posts to learn more about various types of receptors, cell-based assays, and their use in drug discovery and environmental testing applications. 

 

Oxytocin Receptor in Disease and Drug Discovery

Nuclear Receptors and Cancer Research: Current Trends and Applications The Oxytocin Receptor (OXTR) What is the Oxytocin Receptor (OXTR)? The Oxytocin Receptor (OXTR) is a vital component of the human body’s neuroendocrine system, primarily associated with social behavior, reproductive functions, and emotional regulation. The Oxytocin Receptor belongs to the G protein-coupled receptor (GPCR) family, playing…

Alpha-1 Adrenergic Receptors in Disease and Drug Discovery

Nuclear Receptors and Cancer Research: Current Trends and Applications Adrenergic receptors, a class of G protein-coupled receptors (GPCRs), play a pivotal role in mediating the physiological effects of the sympathetic nervous system which is responsible for “fight-or-flight” response. These receptors are integral components of the human body’s response to stress, regulating a multitude of functions…

Adrenergic Receptors In Disease and Drug Discovery

Nuclear Receptors and Cancer Research: Current Trends and Applications Adrenergic receptors, a class of G protein-coupled receptors (GPCRs), play a pivotal role in mediating the physiological effects of the sympathetic nervous system which is responsible for the “fight-or-flight” response. These receptors are integral components of the human body’s response to stress, regulating a multitude of…

Therapeutic Drug Repurposing: Finding New Applications for Existing Drugs through Nuclear Receptor Profiling

Nuclear Receptors and Cancer Research: Current Trends and Applications What is Drug Repurposing? As drug discovery continues to look towards smaller and smaller patient pools and hyper-specific disease states, the demand for new drugs grows rampant. Combined with a lengthy development timeline and massive costs, the development process for new chemical entities (NCEs) is unable…

Colony-Stimulating Factor Receptors G-CSFR, M-CSFR, and GM-CSFR in Disease and Drug Discovery

Nuclear Receptors and Cancer Research: Current Trends and Applications About Colony-Stimulating Factor Receptors G-CSFR, M-CSFR, and GM-CSFR Granulocyte Colony-Stimulating Factor Receptor, Macrophage Colony-Stimulating Factor Receptor, and Granulocyte Macrophage Colony-Stimulating Factor Receptor are members of a family of  transmembrane receptors that play a key role in immune regulation and myeloid cell function making them attractive targets…