Carnosic acid (CA) and carnosol (CS) are components of rosemary reported to possess antioxidative and peroxisome proliferator-activated receptor gamma (PPARγ) transcriptional activities that are useful for preventing metabolic disorders. The aims of this study were to identify new bioactive compounds in heated rosemary and examine their effects on antioxidative stress and PPARγ activation. In heated rosemary, we found five CA-and CS-related compounds and determined their structures by mass spectrometry and nuclear magnetic resonance analyses. Three compounds were identified as dehydromiltirone (1), miltiodiol (2), and miltirone (4), whereas two compounds (3 and 5) were newly discovered molecules. We examined their antioxidant activities and found that 2 and 3 showed strong activity. Furthermore, in PPARγ−transactivation and adipocyte-differentiation assays, compounds 3 and 5showed more potent PPARγ agonistic activity than CA.
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Date of publication: 16 January 2019 (online), April 2019 (print); Phytochemistry Letters, vol. 30
Author information: Yu Buchin (1); Yuka Sakemi (2); Ruriko Hamashima (2); Yuko Morioka (2); Daisuke Yamanak (1, 3); Fumihiko Hakuno (1); Shin-ichiro Takahashi (1); & Kazutoshi Shindo
(1) Department of Animal Sciences, Graduate School of Agricultural and Life Sciences, The Univeristy of Tokyo, Tokyo, Japan
(2) Department of Food and Nutrition, Japan Women’s University, 2-8-1 Mejirodai, Bunkyo-ku, Tokyo 112-8691, Japan
(3) Department of Veterinary Medical Sciences, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan