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  • ABOUT
    • About INDIGO
    • Why INDIGO
    • Key Personnel
      • Board of Directors & Advisors
      • Management
    • Employment
    • INDIGO Press Releases
    • INDIGO in the News
  • ASSAYS
    • By Receptor
    • By Disease State
      • Overview
      • Anemia & Kidney Disease
      • Autoimmune Disease & Inflammation
      • Cancer
      • Cardiovascular Disease
      • Diabetes
      • Endocrinology
      • NAFLD/NASH
      • Obesity
    • Toxicology Solutions
      • In Vitro Toxicology Platform
      • Gene Expression
      • MDR1 / Human P-Glycoprotein
      • Discovery Toxicology
      • Environmental Monitoring
    • INDIGlo Luciferase Detection Reagent
    • Live Cell Multiplex
    • Ortholog Assays
    • Custom Assay Development
  • TECHNOLOGY
    • Nuclear Receptor Overview
    • Assay Kit Platform & Formats
    • Nuclear Receptor Profiling & Panels
    • Environmental Testing Solutions
    • Growth Factor Receptors
    • upcyte® Hepatocytes
    • FAQ
  • RESOURCES
    • Technical Manuals
    • Safety Data Sheets
    • Scientific Whitepapers from INDIGO
    • Scientific Posters
    • New Research Publications
    • Nuclear Receptor Resource
  • CONTACT US
    • Contact INDIGO
    • Request a Quote
    • Request Information
    • Distributors
    • Terms & Conditions
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      • Limited Use Disclosures
  • BLOG

Structure Based Multitargeted Molecular Docking Analysis of Selected Furanocoumarins against Breast Cancer

ABSTRACT Breast cancer is one of the biggest global dilemmas and its current therapy is to target the hormone receptors by the use of partial agonists/antagonists. Potent drugs for breast cancer treatment are Tamoxifen, Trastuzumab, Paclitaxel, etc. which show adverse effects and resistance in patients. The aim of the study has been on certain phytochemicalsRead More

Filed Under: New Publications Tagged With: breast cancer, EGFR, ER alpha, ERa, mTOR, PGR

Involvement of estrogen receptor α in pro-pruritic and pro-inflammatory responses in a mouse model of allergic dermatitis

ABSTRACT It has been reported that endogenous or exogenous estrogens can affect the immune system, resulting in immune disorders; however, their direct involvement in such conditions remains to be demonstrated. The purpose of this study was to investigate whether estrogen receptors (ER) are directly implicated in pro-pruritic and pro-inflammatory reactions in cutaneous allergy. Initially, enhancement of the pro-inflammatoryRead More

Filed Under: New Publications Tagged With: Allergic dermatitis, ER alpha, ERa, Estrogen receptor α, IL-33, Inflammation, Keratinocyte, ortholog, TSLP

Novel synthesised flavone derivatives provide significant insight into the structural features required for enhanced anti-proliferative activity

ABSTRACT With many cancers showing resistance to current chemotherapies, the search for novel anti-cancer agents is attracting considerable attention. Natural flavonoids have been identified as useful leads in such programmes. However, since an in-depth understanding of the structural requirements for optimum activity is generally lacking, further research is required before the full potential of flavonoids as anti-proliferative agentsRead More

Filed Under: New Publications Tagged With: er, ER alpha, ERa

Estrogen Receptor Alpha (ERα; NR3A1)

Estrogen Receptor Alpha (ERα; NR3A1) Product Family Product Number Product Description Technical Manual IB0040 ERα (NR3A1) IB00401-32 Human ERα Reporter Assay System, 3 x 32 assays in 96-well format Technical Manual IB00401 Human ERα Reporter Assay System, 1 x 96-well format assays Technical Manual IB00402 Human ERα Reporter Assay System, 1 x 384-well format assaysRead More

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