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  • HOME
  • ABOUT
    • About
    • Why INDIGO
    • Key Personnel
      • Board of Directors & Advisors
      • Management
    • Investor & Business Relations
  • PRODUCTS
    • Assays
    • In Vitro Toxicology Platform
    • MDR1 / Human P-Glycoprotein
    • Gene Expression
    • NASH Nuclear Receptors For Research
    • Disease States
    • Live Cell Multiplex
    • Custom Assay Development
  • TECHNICAL
    • Nuclear Receptor Profiling & Panels
    • Assay Kit Platform & Formats
    • FAQ
    • Product Policies
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  • CONTACT US
    • Contact INDIGO
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  • RESOURCES
    • Blog
    • Nuclear Receptor Resource
    • New Research Publications
    • INDIGO Press Releases
    • Scientific Posters
    • INDIGO in the News

A synthesis strategy for tetracyclic terpenoids leads to agonists of ERβ

ABSTRACT Natural product and natural product-like molecules continue to be important for the development of pharmaceutical agents, as molecules in this class play a vital role in the pipeline for new therapeutics. Among these, tetracyclic terpenoids are privileged, with >100 being FDA-approved drugs. Despite this significant pharmaceutical success, there remain considerable limitations to broad medicinalRead More

Filed Under: New Publications Tagged With: ER beta, ERb, natural product synthesis

Mechanism and therapeutic window of a genistein nanosuspension to protect against hematopoietic-acute radiation syndrome

ABSTRACT There are no FDA-approved drugs that can be administered prior to ionizing radiation exposure to prevent hematopoietic–acute radiation syndrome (H-ARS). A suspension of synthetic genistein nanoparticles was previously shown to be an effective radioprotectant against H-ARS when administered prior to exposure to a lethal dose of total body radiation. Here we aimed to determineRead More

Filed Under: New Publications Tagged With: ER beta, ERb, ERβ, estrogen receptor, H-ARS, hematopoietic-acute radiation syndrome, radiation, radioprotectant

A-C Estrogens as Potent and Selective Estrogen Receptor-Beta Agonists (SERBAs) to Enhance Memory Consolidation under Low-Estrogen Conditions

ABSTRACT Estrogen receptor-beta (ERβ) is a drug target for memory consolidation in postmenopausal women. Herein is reported a series of potent and selective ERβ agonists (SERBAs) with in vivo efficacy that are A–C estrogens, lacking the B and D estrogen rings. The most potent and selective A–C estrogen is selective for activating ER relative toRead More

Filed Under: New Publications Tagged With: ER isoform selectivity, ERb, SERBAs

Evaluation of estrogenic potential by herbal formula, HPC 03 for in vitro and in vivo

ABSTRACT HPC 03 is herbal formula that consists of extracts from Angelica gigas, Cnidium officinale Makino and Cinnamomum cassia Presel. The present study evaluated the estrogenic potential of HPC 03 by using in vitro and in vivo models. The regulatory mechanisms of HPS 03 in estrogen-dependent MCF-7 cells were assessed. HPC 03 induced the proliferation of estrogen receptor-positive MCF-7 cells, andRead More

Filed Under: New Publications Tagged With: ERa, ERb, estrogen receptor, HPC 03, tamoxifen

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