ABSTRACT Although several potent bile acid Farnesoid X receptor (FXR) and Takeda G-protein-coupled receptor 5 (TGR5, GPBAR1) dual agonists such as INT-767 have been reported, no non-bile acid FXR/TGR5 dual agonist has been investigated to date. Therefore, we attempted to discover potent non-bile acid FXR/TGR5 dual agonists and identified some non-bile acid FXR/TGR5 dual agonists,Read More
COMPOSITIONS AND METHODS FOR TREATING CHOLESTATIC DISEASE
ABSTRACT The invention provides compositions and methods for use in the treatment and prevention of cholestatic diseases. To read the full Patent, click HERE. Date of publication: 14 January 2021; United States Patent Application 20210008128 Inventor Information: Nandakumar, Madhumitha (Arlington, MA, US), Liou, Alice Peiyu (Somerville, MA, US), Halvorsen, Elizabeth Moritz (Malden, MA, US), Mckenzie,Read More
Bacterial metabolism of bile acids promotes generation of peripheral regulatory T cells
ABSTRACT Intestinal health relies on the immunosuppressive activity of CD4+ regulatory T (Treg) cells. Expression of the transcription factor Foxp3 defines this lineage, and can be induced extrathymically by dietary or commensal-derived antigens in a process assisted by a Foxp3 enhancer known as conserved non-coding sequence 1 (CNS1). Products of microbial fermentation including butyrate facilitate the generationRead More
Farnesoid X Receptor (FXR; NR1H4)
Farnesoid X Receptor (FXR; NR1H4) Product Family Product Number Product Description Technical Manual IB0060 FXR (NR1H4) IB00601-32 Human FXR Reporter Assay System, 3 x 32 assays in 96-well format Technical Manual IB00601 Human FXR Reporter Assay System, 1 x 96-well format assays Technical Manual IB00602 Human FXR Reporter Assay System, 1 x 384-well format assaysRead More