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  • HOME
  • ABOUT
    • About
    • Why INDIGO
    • Key Personnel
      • Board of Directors & Advisors
      • Management
  • PRODUCTS
    • Assays
    • Ortholog Assays
    • Growth Factor Receptors
    • In Vitro Toxicology Platform
    • MDR1 / Human P-Glycoprotein
    • Gene Expression
    • NASH Nuclear Receptors For Research
    • Disease States
    • Live Cell Multiplex
    • Custom Assay Development
  • TECHNICAL
    • Nuclear Receptor Profiling & Panels
    • Assay Kit Platform & Formats
    • FAQ
    • Discovery Toxicology
    • upcyte® Hepatocytes
    • Technical Manuals & Product Listing
    • Safety Data Sheets
    • Product Policies
    • Terms & Conditions
    • Limited Use Disclosures
  • CONTACT US
    • Contact INDIGO
    • Request Information
    • Request a Quote
    • Employment
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  • RESOURCES
    • Blog
    • Nuclear Receptor Resource
    • Scientific Whitepapers from INDIGO
    • New Research Publications
    • Scientific Posters
    • INDIGO Press Releases
    • INDIGO in the News

INDIGO Biosciences Announces Release of Gene Expression Kit Utilizing upcyte® Hepatocytes

Portfolio Expansion Helps Researchers Move to the Next Stage of Discovery Faster State College, PA (December 5, 2018) – INDIGO Biosciences, Inc. (INDIGO), the recognized industry leader in nuclear receptor research, announced the addition of a gene expression assay kit featuring upcyte® hepatocytes to their portfolio. This addition both complements INDIGO’s industry-leading nuclear receptor assays andRead More

Filed Under: press Tagged With: CYP, CYP3A4, gene expression, in vitro, upcyte, upcyte hepatocytes

Validating the Gene Expression of Clinically Relevant CYP450 Enzymes and Transporters in Human upcyte® Hepatocytes to Develop an In Vitro Predictive Tool for DDI

View Full Size Research conducted by: Samaar Maalouf (1), Bruce Sherf(1), & Jack Vanden Huevel (1,2) (1) INDIGO Biosciences, Inc., 1981 Pine Hall Road, State College, PA, USA (2) Center for Molecular Toxicology and Carcinogenesis, 325 Life Sciences Building, Penn State University, University Park, PA 16802, USA Date of publication: 2017

Filed Under: New Publications, Posters Tagged With: cyp450 enzymes, drug-drug interaction, gene expression, In Vitro Toxicology, SOT 2017, upcyte, upcyte hepatocytes

Effects of cranberry extracts on gene expression in THP-1 cells

ABSTRACT Cranberry contains high levels of nutrients and bioactive molecules that have health-promoting properties. The purpose of the present studies was to determine if cranberry extracts (CEs) contain phytochemicals that exert anti-inflammatory effects. The human monocytic cell line THP-1 was treated with two CEs (CE and 90MX) and subsequently challenged with Lipopolysaccharides (LPS). Tumor necrosisRead More

Filed Under: New Publications Tagged With: gene expression

Inhibition of Mitochondrial Gene Expression by Nucleoside Analogues and Delayed Mitochondrial Dysfunction

Inhibition of Mitochondrial Gene Expression by Nucleoside Analogues and Delayed Mitochondrial Dysfunction

View Full Size Research conducted by: Midhun Korrapati(1), Koji Toyokawa (1), Bruce Sherf (1), & Jack Vanden Huevel (1,2) (1) INDIGO Biosciences, Inc., 1981 Pine Hall Rd, State College, PA, USA (2) Center for Molecular Toxicology and Carcinogenesis, 325 Life Sciences Building, Penn State University, University Park, PA 16802, USA Date of publication: March 2016

Filed Under: New Publications, Posters Tagged With: gene expression, mitochondrial gene expression, MitoVir

INDIGO Now Offers Profiling of Genes Regulated by Nuclear Receptors

“Critical Step in Understanding the downstream genomic impact of interactions with nuclear receptors” State College, Pennsylvania, July 23, 2015 INDIGO Biosciences Inc., a recognized industry-leading provider of nuclear receptor products and services, announced today that it has expanded its service portfolio by offering analyses of nuclear receptor regulated genes. Gene expression is a widely used approachRead More

Filed Under: press Tagged With: gene expression

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