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  • HOME
  • ABOUT
    • About
    • Why INDIGO
    • Key Personnel
      • Board of Directors & Advisors
      • Management
  • PRODUCTS
    • Assays
    • Ortholog Assays
    • Growth Factor Receptors
    • In Vitro Toxicology Platform
    • MDR1 / Human P-Glycoprotein
    • Gene Expression
    • NASH Nuclear Receptors For Research
    • Disease States
    • Live Cell Multiplex
    • Custom Assay Development
  • TECHNICAL
    • Nuclear Receptor Profiling & Panels
    • Assay Kit Platform & Formats
    • FAQ
    • Discovery Toxicology
    • upcyte® Hepatocytes
    • Technical Manuals & Product Listing
    • Safety Data Sheets
    • Product Policies
    • Terms & Conditions
    • Limited Use Disclosures
  • CONTACT US
    • Contact INDIGO
    • Request Information
    • Request a Quote
    • Employment
    • Distributors
  • RESOURCES
    • Blog
    • Nuclear Receptor Resource
    • Scientific Whitepapers from INDIGO
    • New Research Publications
    • Scientific Posters
    • INDIGO Press Releases
    • INDIGO in the News

Zebrafish Glucocorticoid Receptor (zGR; nr3c1)

Zebrafish Glucocorticoid Receptor (zGR; nr3c1) Product Family Product Number Product Description Technical Manual Z0020 zGR (nr3c1) Z00201-32 Zebrafish GR Reporter Assay System, 3 x 32 assays in 96-well format Technical Manual Z00201 Zebrafish GR Reporter Assay System, 1 x 96-well format assays Technical Manual

Nuclear Receptors Regulate Intestinal Inflammation in the Context of IBD

ABSTRACT Gastrointestinal (GI) homeostasis is strongly dependent on nuclear receptor (NR) functions. They play a variety of roles ranging from nutrient uptake, sensing of microbial metabolites, regulation of epithelial intestinal cell integrity to shaping of the intestinal immune cell repertoire. Several NRs are associated with GI pathologies; therefore, systematic analysis of NR biology, the underlyingRead More

Filed Under: New Publications Tagged With: glucocorticoids, GR, ibd, Inflammation, intestinal inflammation, nuclear receptors, PPARγ, PXR, VDR

JTP-117968, a novel selective glucocorticoid receptor modulator, exhibits improved transrepression/transactivation dissociation

ABSTRACT Classic glucocorticoids that have outstanding anti-inflammatory effects are still widely prescribed for the treatment of various inflammatory and autoimmune diseases. Conversely, glucocorticoids cause numerous unwanted side effects, particularly systemically dosed glucocorticoids. Therefore, selective glucocorticoid receptor modulator (SGRM), which maintains beneficial anti-inflammatory effects while reducing the occurrence of side effects, is one of the mostRead More

Filed Under: New Publications Tagged With: glucocorticoid receptor, GR, selective glucocorticoid receptor modulator, sgrm

Oxysterols are agonist ligands of RORγt and drive Th17 cell differentiation

ABSTRACT The RAR-related orphan receptor gamma t (RORγt) is a nuclear receptor required for generating IL-17–producing CD4+ Th17 T cells, which are essential in host defense and may play key pathogenic roles in autoimmune diseases. Oxysterols elicit profound effects on immune and inflammatory responses as well as on cholesterol and lipid metabolism. Here, we describe the identification of several naturally occurringRead More

Filed Under: New Publications Tagged With: CAR, er, FXR, GR, PPAR, PPARα, PPARβ, PPARγ, ROR, RORγ, RORγt

Structural Stereochemistry of Androstane Hormones Determines Interactions with Human Androgen, Estrogen, and Glucocorticoids Receptors

ABSTRACT DHEA, 17α-AED, 17β-AED, and 17β-AET exhibit strong biological activity that has been attributed to androgenic, estrogenic, or antiglucocorticoid activity in vivo and in vitro. This study compared DHEA, 17α-AED, 17β-AED, and 17β-AET for their ability to activate the human AR, ER, and GR and determine the relative androgenicity, estrogenicity, and glucocorticoid activity. The results show that, at theRead More

Filed Under: New Publications Tagged With: AR, er, GR

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