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  • ABOUT
    • About INDIGO
    • Why INDIGO
    • Key Personnel
      • Board of Directors & Advisors
      • Management
    • Employment
    • INDIGO Press Releases
    • INDIGO in the News
  • ASSAYS
    • By Receptor
    • By Disease State
      • Overview
      • Anemia & Kidney Disease
      • Autoimmune Disease & Inflammation
      • Cancer
      • Cardiovascular Disease
      • Diabetes
      • Endocrinology
      • NAFLD/NASH
      • Obesity
    • Toxicology Solutions
      • In Vitro Toxicology Platform
      • Gene Expression
      • MDR1 / Human P-Glycoprotein
      • Discovery Toxicology
      • Environmental Monitoring
    • INDIGlo Luciferase Detection Reagent
    • Live Cell Multiplex
    • Ortholog Assays
    • Custom Assay Development
  • TECHNOLOGY
    • Nuclear Receptor Overview
    • Assay Kit Platform & Formats
    • Nuclear Receptor Profiling & Panels
    • Environmental Testing Solutions
    • Growth Factor Receptors
    • upcyte® Hepatocytes
    • FAQ
  • RESOURCES
    • Technical Manuals
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  • CONTACT US
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  • BLOG

Characterization of a novel non-steroidal glucocorticoid receptor agonist optimized for topical treatment

ABSTRACT Glucocorticoids (GCs) are commonly used topical treatments for skin diseases but are associated with both local and systemic side effects. In this study, we describe a selective non-steroidal glucocorticoid receptor (GR) agonist for topical use, LEO 134310, which is rapidly deactivated in the blood resulting in low systemic exposure and a higher therapeutic indexRead More

Filed Under: New Publications Tagged With: GR, MR, MR assay

A ready-to-use, thermoresponsive, and extended-release delivery system for the paranasal sinuses

Abstract A drug delivery system for the paranasal sinuses consisting of a freeze-dried thermoresponsive hydrogel with degradable microspheres, called FD-TEMPS (Freeze Dried—Thermogel, Extended-release Microsphere-based delivery to the Paranasal Sinuses), was developed. Glass transition temperatures (Tg′) of the maximally freeze concentrated solutions consisting of poly(N-isopropylacrylamide) (pNIPAAm) and polyethylene glycol (PEG) were determined by differential scanning calorimetry,Read More

Filed Under: New Publications Tagged With: glucocorticoid receptor assay, GR

A thermoresponsive hydrogel system for long-acting corticosteroid delivery into the paranasal sinuses

ABSTRACT Delivering localized treatment to the paranasal sinuses for diseases such as chronic rhinosinusitis (CRS) is particularly challenging because of the small natural openings leading from the sinuses that can be further obstructed by presence of inflammation. As such, oral steroids, topical nasal sprays or irrigation, and surgery can be utilized to treat persistent sinonasalRead More

Filed Under: New Publications Tagged With: GR, Mineralocorticoid Receptor

Zebrafish Glucocorticoid Receptor (zGR; nr3c1)

Zebrafish Glucocorticoid Receptor (zGR; nr3c1) Product Family Product Number Product Description Technical Manual Z0020 zGR (nr3c1) Z00201-32 Zebrafish GR Reporter Assay System, 3 x 32 assays in 96-well format Technical Manual Z00201 Zebrafish GR Reporter Assay System, 1 x 96-well format assays Technical Manual

Gene Expression: Nuclear Receptors

INTRODUCTION There are four main classes of receptors, Ion channels, G-protein coupled (GPCR), receptor tyrosine kinase and soluble (also called intracellular) receptors. The first three have ligands that are mainly present in the extracellular space (water soluble ligands). The binding of ligand causes a change in the shape/function of the protein that generates a signalRead More

Filed Under: Whitepapers Tagged With: AhR, AR, ERa, ERb, gene expression, GR, PGR, RAR, TRa, TRb, VDR

Nuclear Receptors Regulate Intestinal Inflammation in the Context of IBD

ABSTRACT Gastrointestinal (GI) homeostasis is strongly dependent on nuclear receptor (NR) functions. They play a variety of roles ranging from nutrient uptake, sensing of microbial metabolites, regulation of epithelial intestinal cell integrity to shaping of the intestinal immune cell repertoire. Several NRs are associated with GI pathologies; therefore, systematic analysis of NR biology, the underlyingRead More

Filed Under: New Publications Tagged With: glucocorticoids, GR, ibd, Inflammation, intestinal inflammation, nuclear receptors, PPARγ, PXR, VDR

Quizalofop-p-ethyl induces adipogenesis in 3T3-L1 adipocytes

ABSTRACT Exposure to endocrine disrupting chemicals is an established risk factor for obesity. The most commonly used pesticide active ingredients have never been tested in an adipogenesis assay. We tested for the first time the potential of glyphosate, 2,4-dichlorophenoxyacetic acid, dicamba, mesotrione, isoxaflutole and quizalofop-p-ethyl (QpE) to induce lipid accumulation in murine 3T3-L1 adipocytes. OnlyRead More

Filed Under: New Publications Tagged With: adipocytes, endocrine disruptors, ERa, ERb, estrogen antagonists, fat metabolism, glucocorticoid receptor, glucocorticoid receptor antagonists, GR, obesity, pesticides, rosiglitazone, triglycerides

JTP-117968, a novel selective glucocorticoid receptor modulator, exhibits improved transrepression/transactivation dissociation

ABSTRACT Classic glucocorticoids that have outstanding anti-inflammatory effects are still widely prescribed for the treatment of various inflammatory and autoimmune diseases. Conversely, glucocorticoids cause numerous unwanted side effects, particularly systemically dosed glucocorticoids. Therefore, selective glucocorticoid receptor modulator (SGRM), which maintains beneficial anti-inflammatory effects while reducing the occurrence of side effects, is one of the mostRead More

Filed Under: New Publications Tagged With: glucocorticoid receptor, GR, selective glucocorticoid receptor modulator, sgrm

Rat Glucocorticoid Receptor (rGR; nr3c1)

Rat Glucocorticoid Receptor (rGR; nr3c1) Product Family Product Number Product Description Technical Manual R0020 rGR (nr3c1) R00201-32 Rat GR Reporter Assay System, 3 x 32 assays in 96-well format Technical Manual R00201 Rat GR Reporter Assay System, 1 x 96-well format assays Technical Manual

Glucocorticoid Receptor (GR; NR3C1)

Glucocorticoid Receptor (GR; NR3C1) Product Family Product Number Product Description Technical Manual IB0020 GR (NR3C1) IB00201-32 Human GR Reporter Assay System, 3 x 32 assays in 96-well format Technical Manual IB00201 Human GR Reporter Assay System, 1 x 96-well format assays Technical Manual IB00202 Human GR Reporter Assay System, 1 x 384-well format assays TechnicalRead More

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