ABSTRACT N-Arachidonoyl-ethanolamine (AEA) is an endocannabinoid (eCB) and endogenous lipid mimicking many of the effects of Δ9-tetrahydrocannabinol, notably on brain functions, appetite, pain and inflammation. The eCBs and eCB-like compounds contain fatty acids, the main classes being the monoacylglycerols and the N-acyl-ethanolamines (NAEs). Thus, each long chain fatty acid likely exists under the form ofRead More
Nuclear Receptors Regulate Intestinal Inflammation in the Context of IBD
ABSTRACT Gastrointestinal (GI) homeostasis is strongly dependent on nuclear receptor (NR) functions. They play a variety of roles ranging from nutrient uptake, sensing of microbial metabolites, regulation of epithelial intestinal cell integrity to shaping of the intestinal immune cell repertoire. Several NRs are associated with GI pathologies; therefore, systematic analysis of NR biology, the underlyingRead More
Involvement of estrogen receptor α in pro-pruritic and pro-inflammatory responses in a mouse model of allergic dermatitis
ABSTRACT It has been reported that endogenous or exogenous estrogens can affect the immune system, resulting in immune disorders; however, their direct involvement in such conditions remains to be demonstrated. The purpose of this study was to investigate whether estrogen receptors (ER) are directly implicated in pro-pruritic and pro-inflammatory reactions in cutaneous allergy. Initially, enhancement of the pro-inflammatoryRead More
Peroxisome Proliferator-Activated Receptor Gamma (PPARγ; NR1C3)
Peroxisome Proliferator-Activated Receptor Gamma (PPARγ; NR1C3) Product Family Product Number Product Description Technical Manual IB0010 PPARγ (NR1C3) IB00101-32 Human PPARγ Reporter Assay System, 3 x 32 assays in 96-well format Technical Manual IB00101 Human PPARγ Reporter Assay System, 1 x 96-well format assays Technical Manual IB00102 Human PPARγ Reporter Assay System, 1 x 384-well formatRead More
Peroxisome Proliferator-Activated Receptor Beta/Delta (PPARδ/PPARβ; NR1C2)
Peroxisome Proliferator-Activated Receptor Beta/Delta (PPARδ/PPARβ; NR1C2) Product Family Product Number Product Description Technical Manual IB0012 PPARδ (NR1C2) IB00121-32 Human PPARδ Reporter Assay System, 3 x 32 assays in 96-well format Technical Manual IB00121 Human PPARδ Reporter Assay System, 1 x 96-well format assays Technical Manual IB00122 Human PPARδ Reporter Assay System, 1 x 384-well formatRead More
NF-kB Assay
Nuclear Factor kappa-light-chain enhancer of activated B cells (NF-kB) Product Family Product Number Product Description Technical Manual IB0900 NF-kB IB09001-32 Human NF-kB Reporter Assay System, 3 x 32 assays in 96-well format Technical Manual IB09001 Human NF-kB Reporter Assay System, 1 x 96-well format assays Technical Manual IB09002 Human NF-kB Reporter Assay System, 1 xRead More
Glucocorticoid Receptor (GR; NR3C1)
Glucocorticoid Receptor (GR; NR3C1) Product Family Product Number Product Description Technical Manual IB0020 GR (NR3C1) IB00201-32 Human GR Reporter Assay System, 3 x 32 assays in 96-well format Technical Manual IB00201 Human GR Reporter Assay System, 1 x 96-well format assays Technical Manual IB00202 Human GR Reporter Assay System, 1 x 384-well format assays TechnicalRead More