Nuclear Hormone Receptor General Overview Nuclear Hormone Receptor Introduction Unlike receptors found on the cell surface, members of the nuclear hormone receptor (NR) superfamily are restricted to metazoan organisms such as nematodes, insects, and vertebrates. These proteins are intracellular transcription factors that directly regulate gene expression in response to lipophilic molecules. They affect a wideRead More
Nuclear Receptor Assays
Nuclear Receptor Assays INDIGO’s Nuclear Receptor Assays are reporter assays for intracellular transcription factors that directly regulate gene expression in response to lipophilic molecules commonly referred to as nuclear receptors (NRs). Nuclear receptors affect a wide variety of functions, including fatty acid metabolism, reproductive development, and detoxification of foreign substances. Many NRs act as ligand-inducibleRead More
Disruption of Nuclear Receptor Signaling Alters Triphenyl Phosphate-Induced Cardiotoxicity in Zebrafish Embryos
ABSTRACT Triphenyl phosphate (TPHP) is an unsubstituted aryl phosphate ester used as a flame retardant and plasticizer within the United States. Using zebrafish as a model, the objectives of this study were to rely on (1) mRNA-sequencing to uncover pathways disrupted following embryonic TPHP exposure and (2) high-content screening to identify nuclear receptor ligands thatRead More
INDIGO Offers NF-κB Assay Systems
New Assay Critical to the Study of the Human Immune Responses and Cancers State College, PA (October 16, 2014) – INDIGO Biosciences, a leading provider of nuclear receptor products and services announced today that it has released a new nuclear factor kappa-light-chain enhancer of activated B cells (NF-κB) assay system. Three different assay kit formatsRead More
INDIGO Offers Human Estrogen-related Receptor Gamma Assay System
New Assay to Test Target Compounds for Anti-Obesity Therapeutics State College, PA (September 18, 2014) – INDIGO Biosciences, a leading provider of nuclear receptor products and services announced today that it has released a new Human Estrogen-related Orphan Receptor Gamma (NR3B3; ERRγ) Assay System. Three different assay kits are available. ERRg is naturally expressed inRead More
New Human Aryl Hydrocarbon Receptor Reporter Assay System Kit Offers Convenience, Assay Sensitivity and Reliable Results
State College, PA (August 14, 2014) – INDIGO Biosciences, a research products and services company focused on nuclear receptor screenings, announced today that it has released new cell-based Aryl Hydrocarbon Receptor (AhR) reporter assay kits. The Aryl Hydrocarbon Receptor (AhR) Assay employs the luciferase reporter gene technology, and is used for screening test samples toRead More