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Nuclear Receptor & In Vitro Toxicology Solutions™

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  • ABOUT
    • About INDIGO
    • Why INDIGO
    • Key Personnel
      • Board of Directors & Advisors
      • Management
    • Employment
    • INDIGO Press Releases
    • INDIGO in the News
  • ASSAYS
    • By Receptor
    • By Disease State
      • Overview
      • Anemia & Kidney Disease
      • Autoimmune Disease & Inflammation
      • Cancer
      • Cardiovascular Disease
      • Diabetes
      • Endocrinology
      • NAFLD/NASH
      • Obesity
    • Toxicology Solutions
      • In Vitro Toxicology Platform
      • Gene Expression
      • MDR1 / Human P-Glycoprotein
      • Discovery Toxicology
      • Environmental Monitoring
    • INDIGlo Luciferase Detection Reagent
    • Live Cell Multiplex
    • Ortholog Assays
    • Custom Assay Development
  • TECHNOLOGY
    • Nuclear Receptor Overview
    • Assay Kit Platform & Formats
    • Nuclear Receptor Profiling & Panels
    • Environmental Testing Solutions
    • Growth Factor Receptors
    • upcyte® Hepatocytes
    • FAQ
  • RESOURCES
    • Technical Manuals
    • Safety Data Sheets
    • Scientific Whitepapers from INDIGO
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    • New Research Publications
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  • CONTACT US
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  • BLOG

Rabbit Progesterone Receptor (rbPGR; nr3c3)

Rabbit Progesterone Receptor (rbPGR; nr3c3) Product Family Product Number Product Description Technical Manual RB0500 rPGR (nr3c3) RB05001-32 Rabbit PGR Reporter Assay System, 3 x 32 assays in 96-well format Technical Manual RB05001 Rabbit PGR Reporter Assay System, 1 x 96-well format assays Technical Manual hbspt.cta.load(4439249, ‘7ffba944-40f7-40e0-a256-15b59ce1150b’, {});

Cyn Monkey Progesterone Receptor (cPGR; nr3c3)

Cyn Monkey Progesterone Receptor (cPGR; nr3c3) Product Family Product Number Product Description Technical Manual C0500 rPGR (nr3c3) C05001-32 Cyn Monkey PGR Reporter Assay System, 3 x 32 assays in 96-well format Technical Manual C05001 Cyn Monkey PGR Reporter Assay System, 1 x 96-well format assays Technical Manual hbspt.cta.load(4439249, ‘7ffba944-40f7-40e0-a256-15b59ce1150b’, {});

Rat Progesterone Receptor (rPGR; nr3c3)

Rat Progesterone Receptor (rPGR; nr3c3) Product Family Product Number Product Description Technical Manual R0500 rPGR (nr3c3) R05001-32 Rat PGR Reporter Assay System, 3 x 32 assays in 96-well format Technical Manual R05001 Rat PGR Reporter Assay System, 1 x 96-well format assays Technical Manual

Gene Expression: Nuclear Receptors

INTRODUCTION There are four main classes of receptors, Ion channels, G-protein coupled (GPCR), receptor tyrosine kinase and soluble (also called intracellular) receptors. The first three have ligands that are mainly present in the extracellular space (water soluble ligands). The binding of ligand causes a change in the shape/function of the protein that generates a signalRead More

Filed Under: Whitepapers Tagged With: AhR, AR, ERa, ERb, gene expression, GR, PGR, RAR, TRa, TRb, VDR

Structure Based Multitargeted Molecular Docking Analysis of Selected Furanocoumarins against Breast Cancer

ABSTRACT Breast cancer is one of the biggest global dilemmas and its current therapy is to target the hormone receptors by the use of partial agonists/antagonists. Potent drugs for breast cancer treatment are Tamoxifen, Trastuzumab, Paclitaxel, etc. which show adverse effects and resistance in patients. The aim of the study has been on certain phytochemicalsRead More

Filed Under: New Publications Tagged With: breast cancer, EGFR, ER alpha, ERa, mTOR, PGR

Bioactive Rearrangement Products from Aqueous Photolysis of Pharmaceutical Steroids

ABSTRACT In an ongoing effort to study the environmental fate of endocrine-active steroid hormones, we report the formation of phenolic rearrangement products (3 and 4) with a novel 6,5,8,5-ring system following aqueous photolysis of dienogest (1) and methyldienolone(2). The structures were established by analysis of 2D NMR and HRMS data, and that of 3 wasRead More

Filed Under: New Publications Tagged With: AR, environmental, ERa, ERb, PGR, PR

Nestorone® (NES) a Novel Progestin for Non-oral Contraception: Structure-activity Relationships and Brain Metabolism Studies

ABSTRACT Nestorone® (NES) is a highly potent non-androgenic progestin being developed for contraception. NES is a synthetic progestin that may possess neuroprotective and myelin regenerative potential as an added health benefits. In receptor transactivation experiments, NES displayed greater potency than progesterone to transactivate the human progesterone receptor (hPR). This was confirmed by docking experiments whichRead More

Filed Under: New Publications Tagged With: PGR

Progesterone Receptor (PGR; NR3C3)

Progesterone Receptor (PGR; NR3C3) Product Family Product Number Product Description Technical Manual IB0500 PGR (NR3C3) IB05001-32 Human PGR Reporter Assay System, 3 x 32 assays in 96-well format Technical Manual IB05001 Human PGR Reporter Assay System, 1 x 96-well format assays Technical Manual IB05002 Human PGR Reporter Assay System, 1 x 384-well format assays TechnicalRead More

New Human Progesterone Receptor (PGR) Assay System from INDIGO Biosciences

A robust, off-the-shelf solution for screening Human Progesterone Receptor (PGR,PR, NR3C3 ) is now available from INDIGO Biosciences, The Nuclear Receptor Experts. The INDIGO PGR Assay System is the newest offering from the Company’s growing line of cell-based, INDIGO Nuclear Receptor Reporter Assay products for on-demand use in drug discovery and development research and toxicologyRead More

Filed Under: press Tagged With: PGR

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