Rat Progesterone Receptor (rPGR; nr3c3) Product Family Product Number Product Description Technical Manual R0500 rPGR (nr3c3) R05001-32 Rat PGR Reporter Assay System, 3 x 32 assays in 96-well format Technical Manual R05001 Rat PGR Reporter Assay System, 1 x 96-well format assays Technical Manual
Gene Expression: Nuclear Receptors
INTRODUCTION There are four main classes of receptors, Ion channels, G-protein coupled (GPCR), receptor tyrosine kinase and soluble (also called intracellular) receptors. The first three have ligands that are mainly present in the extracellular space (water soluble ligands). The binding of ligand causes a change in the shape/function of the protein that generates a signalRead More
Structure Based Multitargeted Molecular Docking Analysis of Selected Furanocoumarins against Breast Cancer
ABSTRACT Breast cancer is one of the biggest global dilemmas and its current therapy is to target the hormone receptors by the use of partial agonists/antagonists. Potent drugs for breast cancer treatment are Tamoxifen, Trastuzumab, Paclitaxel, etc. which show adverse effects and resistance in patients. The aim of the study has been on certain phytochemicalsRead More
Nestorone® (NES) a Novel Progestin for Non-oral Contraception: Structure-activity Relationships and Brain Metabolism Studies
ABSTRACT Nestorone® (NES) is a highly potent non-androgenic progestin being developed for contraception. NES is a synthetic progestin that may possess neuroprotective and myelin regenerative potential as an added health benefits. In receptor transactivation experiments, NES displayed greater potency than progesterone to transactivate the human progesterone receptor (hPR). This was confirmed by docking experiments whichRead More
Progesterone Receptor (PGR; NR3C3)
Progesterone Receptor (PGR; NR3C3) Product Family Product Number Product Description Technical Manual IB0500 PGR (NR3C3) IB05001-32 Human PGR Reporter Assay System, 3 x 32 assays in 96-well format Technical Manual IB05001 Human PGR Reporter Assay System, 1 x 96-well format assays Technical Manual IB05002 Human PGR Reporter Assay System, 1 x 384-well format assays TechnicalRead More
New Human Progesterone Receptor (PGR) Assay System from INDIGO Biosciences
A robust, off-the-shelf solution for screening Human Progesterone Receptor (PGR,PR, NR3C3 ) is now available from INDIGO Biosciences, The Nuclear Receptor Experts. The INDIGO PGR Assay System is the newest offering from the Company’s growing line of cell-based, INDIGO Nuclear Receptor Reporter Assay products for on-demand use in drug discovery and development research and toxicologyRead More