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Identifying qualitative differences in PPARα signaling networks in human and rat hepatocytes and their significance for next generation chemical risk assessment methods

ABSTRACT In this paper, we evaluate the PPARα signaling network in rats, examining transcriptional responses in primary hepatocytes exposed to a PPARα specific ligand, GW7647. These transcriptomic studies were complemented with ChIP-seq studies of PPARα binding and transcription binding motif identification for PPARα responsive genes. We also conducted a limited study of GW7647 dosing the inRead More

Filed Under: New Publications Tagged With: fit-for-purpose assays, gene expression profiling, in vitro risk assessment, ortholog, PPARα ChIP-seq, PPARα signaling network, TT221C

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