ABSTRACT While studying the environmental fate of potent endocrine-active steroid hormones, we observed the formation of an intramolecular [2+2] photocycloaddition product (2) with a novel hexacyclic ring system following photolysis of altrenogest (1). The structure and absolute configuration were established by X-ray diffraction analysis. Theoretical computations identified a barrierless two-step cyclization mechanism for the formationRead More
Rifamycin SV exhibits strong anti-inflammatory in vitro activity through pregnane X receptor stimulation and NFkB inhibition
ABSTRACTRifamycin SV (rifamycin), is a member of the ansamycin family of antimicrobial compounds which kills bacteria commonly associated with infectious diarrhea and other enteric infections. Rifamycin has been found to be effective in experimental animal models of gut inflammation and its efficacy in these settings has been attributed partially to immunomodulatory non-bactericidal activities. This studyRead More
Pregnane X Receptor (PXR; NR1I2)
Pregnane X Receptor (PXR; NR1I2) Product Family Product Number Product Description Technical Manual IB0700 PXR (NR1I2) IB07001-32 Human PXR Reporter Assay System, 3 x 32 assays in 96-well format Technical Manual IB07001 Human PXR Reporter Assay System, 1 x 96-well format assays Technical Manual IB07002 Human PXR Reporter Assay System, 1 x 384-well format assaysRead More