ABSTRACT Clinical success of IL-17/IL-23 pathway biologics for the treatment of moderate to severe psoriasis suggests that targeting RORγt, a master regulator for the proliferation and function of Th17 cells, could be an effective alternative. However, oral RORγ antagonists (VTP43742, TAK828) with high systemic exposure showed toxicity in phase I/II clinical trials and terminated development.Read More
Metadichol, A Novel ROR Gamma Inverse Agonist and Its Applications in Psoriasis
ABSTRACT Psoriasis affects 3% of the population worldwide, and there is no known cure. Psoriasis is associated with an increased risk of psoriatic arthritis, lymphomas, cardiovascular disease, and Crohn’s disease. Psoriasis treatments today include steroid and vitamin D3 cream, ultraviolet light, and immune system suppressing medications such as methotrexate. The T cells responsible for psoriasisRead More
Vitamin D Receptor (VDR; NR1I1)
Vitamin D Receptor (VDR; NR1I1) Product Family Product Number Product Description Technical Manual IB0070 VDR (NR1I1) IB00701-32 Human VDR Reporter Assay System, 3 x 32 assays in 96-well format Technical Manual IB00701 Human VDR Reporter Assay System, 1 x 96-well format assays Technical Manual IB00702 Human VDR Reporter Assay System, 1 x 384-well format assays
Retinoid X Receptor Gamma (RXRγ; NR2B3)
Retinoid X Receptor Gamma (RXRγ; NR2B3) Product Family Product Number Product Description Technical Manual IB0082 RXRγ (NR2B3) IB00821-32 Human RXRγ Reporter Assay System, 3 x 32 assays in 96-well format Technical Manual IB00821 Human RXRγ Reporter Assay System, 1 x 96-well format assays Technical Manual IB00822 Human RXRγ Reporter Assay System, 1 x 384-well formatRead More
Retinoid X Receptor Alpha (RXRα; NR2B1)
Retinoid X Receptor Alpha (RXRα; NR2B1) Product Family Product Number Product Description Technical Manual IB0080 RXRα (NR2B1) IB00801-32 Human RXRα Reporter Assay System, 3 x 32 assays in 96-well format Technical Manual IB00801 Human RXRα Reporter Assay System, 1 x 96-well format assays Technical Manual IB00802 Human RXRα Reporter Assay System, 1 x 384-well formatRead More
Retinoic Acid Receptor Gamma (RARγ; NR1B3)
Retinoic Acid Receptor Gamma (RARγ; NR1B3) Product Family Product Number Product Description Technical Manual IB0200 RARγ (NR1B3) IB02001-32 Human RARγ Reporter Assay System, 3 x 32 assays in 96-well format Technical Manual IB02001 Human RARγ Reporter Assay System, 1 x 96-well format assays Technical Manual IB02002 Human RARγ Reporter Assay System, 1 x 384-well formatRead More
Retinoic Acid Receptor Beta (RARβ; NR1B2)
Retinoic Acid Receptor Beta (RARβ; NR1B2) Product Family Product Number Product Description Technical Manual IB0210 RARβ (NR1B2) IB02101-32 Human RARβ Reporter Assay System, 3 x 32 assays in 96-well format Technical Manual IB02101 Human RARβ Reporter Assay System, 1 x 96-well format assays Technical Manual IB02102 Human RARβ Reporter Assay System, 1 x 384-well formatRead More
Retinoic Acid Receptor Alpha (RARα; NR1B1)
Retinoic Acid Receptor Alpha (RARα; NR1B1) Product Family Product Number Product Description Technical Manual IB0220 RARα (NR1B1) IB02201-32 Human RARα Reporter Assay System, 3 x 32 assays in 96-well format Technical Manual IB02201 Human RARα Reporter Assay System, 1 x 96-well format assays Technical Manual IB02202 Human RARα Reporter Assay System, 1 x 384-well formatRead More