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  • HOME
  • ABOUT
    • About
    • Why INDIGO
    • Key Personnel
      • Board of Directors & Advisors
      • Management
  • PRODUCTS
    • Assays
    • Ortholog Assays
    • Growth Factor Receptors
    • In Vitro Toxicology Platform
    • MDR1 / Human P-Glycoprotein
    • Gene Expression
    • NASH Nuclear Receptors For Research
    • Disease States
    • Live Cell Multiplex
    • Custom Assay Development
  • TECHNICAL
    • Nuclear Receptor Profiling & Panels
    • Assay Kit Platform & Formats
    • FAQ
    • Discovery Toxicology
    • upcyte® Hepatocytes
    • Technical Manuals & Product Listing
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    • Product Policies
    • Terms & Conditions
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  • CONTACT US
    • Contact INDIGO
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  • RESOURCES
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    • Nuclear Receptor Resource
    • Scientific Whitepapers from INDIGO
    • New Research Publications
    • Scientific Posters
    • INDIGO Press Releases
    • INDIGO in the News

Zebrafish Retinoic Acid Receptor Alpha A (zRARαa; NR1B1 isoform A)

Zebrafish Retinoic Acid Receptor Alpha A (zRARαa; nr1b1 isoform A) Product Family Product Number Product Description Technical Manual Z0220 zRARα (nr1b1 iso A) Z02201-32 Zebrafish RARαa Reporter Assay System, 3 x 32 assays in 96-well format Technical Manual Z02201 Zebrafish RARαa Reporter Assay System, 1 x 96-well format assays Technical Manual

Development and characterization of novel and selective inhibitors of cytochrome P450 CYP26A1, the human liver retinoic acid hydroxylase

ABSTRACT Cytochrome P450 CYP26 enzymes are responsible for all-trans-retinoic acid (atRA) clearance. Inhibition of CYP26 enzymes will increase endogenous atRA concentrations and is an attractive therapeutic target. However, the selectivity and potency of the existing atRA metabolism inhibitors towards CYP26A1 and CYP26B1 is unknown, and no selective CYP26A1 or CYP26B1 inhibitors have been developed. HereRead More

Filed Under: New Publications Tagged With: In Vitro Toxicology, RAR

Triphenyl phosphate-induced developmental toxicity in zebrafish: Potential role of the retinoic acid receptor

ABSTRACT Using zebrafish as a model, we previously reported that developmental exposure to triphenyl phosphate (TPP) – a high-production volume organophosphate-based flame retardant – results in dioxin-like cardiac looping impairments that are independent of the aryl hydrocarbon receptor. Using a pharmacologic approach, the objective of this study was to investigate the potential role of retinoicRead More

Filed Under: New Publications Tagged With: AhR, RAR

Examination of Retinoid-like Compounds for Human RXRs, RARs, and RORs

Examination of Retinoid-like Compounds for Human RXRs, RARs, and RORs

View Full Size Research conducted by: Prajakta Albrecht (1), Koji Toyokawa (1), Ewa Maddox (1), Palmer Cramer (1), Jack Vanden Huevel (1,2), & Bruce Sherf (1) (1) INDIGO Biosciences, Inc., 1981 Pine Hall Rd, State College, PA, USA (2) Center for Molecular Toxicology and Carcinogenesis, 325 Life Sciences Building, Penn State University, University Park, PA 16802,Read More

Filed Under: New Publications, Posters Tagged With: RAR, ROR, RXR

Examination of Specificity of Retinoid-like Compounds for Human RXRs, RARs, and RORs

ABSTRACT Vitamin A (retinol) and its metabolites play many physiological roles including cell differentiation, cell proliferation, energy homeostasis, circadian rhythm and immune response. Vitamin A and its metabolites are known to act through retinoid acid receptors (RARs), retinoid-related orphan receptors (RORs) and retinoid x receptors (RXRs). These receptors are also important drug targets, although theRead More

Filed Under: New Publications Tagged With: RAR, ROR, RXR

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