Abstract RORγ is a dual-functional drug target, which involves not only induction of inflammation but also promotion of cancer immunity. The development of agonists of RORγ promoting Th17 cell differentiation could provide a novel mechanism of action (MOA) as an immune-activating anticancer agent. Herein, we describe new 2-(ortho-substituted benzyl)-indole derivatives as RORγ agonists by scaffoldRead More
Withanolide Derivative 2,3-Dihydro-3β-methoxy Withaferin-A Modulates the Circadian Clock via Interaction with RAR-Related Orphan Receptor α (RORa)
Abstract Withanolide derivatives have anticancer, anti-inflammatory, and other functions and are components of Indian traditional Ayurvedic medicine. Here, we found that 2,3-dihydro-3β-methoxy withaferin-A (3βmWi-A), a derivative of withaferin-A (Wi-A) belonging to a class of withanolides that are abundant in Ashwagandha (Withania somnifera), lengthened the period of the circadian clock. This compound dose-dependently elongated circadian rhythmsRead More
RAR-related Orphan Receptor Alpha (RORα; NR1F1)
RAR-related Orphan Receptor Alpha (RORα; NR1F1) Product Family Product Number Product Description Technical Manual IB0401 RORα (NR1F1) IB04011-32 Human RORα Reporter Assay System, 3 x 32 assays in 96-well format Technical Manual IB04011 Human RORα Reporter Assay System, 1 x 96-well format assays Technical Manual IB04012 Human RORα Reporter Assay System, 1 x 384-well formatRead More