ABSTRACT Endocrine disrupting chemicals (EDCs) are found in every environmental medium and are chemically diverse. Their presence in water resources can negatively impact the health of both human and wildlife. Currently, there are no mandatory screening mandates or regulations for EDC levels in complex water samples globally. Bioassays, which allow quantifying in vivo or inRead More
Gene Expression: Nuclear Receptors
INTRODUCTION There are four main classes of receptors, Ion channels, G-protein coupled (GPCR), receptor tyrosine kinase and soluble (also called intracellular) receptors. The first three have ligands that are mainly present in the extracellular space (water soluble ligands). The binding of ligand causes a change in the shape/function of the protein that generates a signalRead More
Metadichol® A Novel Inverse Agonist of Thyroid Receptor and its Application in Thyroid Diseases
ABSTRACT An estimated 200 million individuals worldwide have a thyroid disorder. Thyroid diseases affect seven times more women than men. People not diagnosed make up the majority of thyroid patients. There is a need to find novel and safe ways to change the underlying disease processes, rather than merely stop excess thyroid hormone production asRead More
Thyroid Hormone Receptor Beta (TRβ; NR1A2)
Thyroid Hormone Receptor Beta (TRβ; NR1A2) Product Family Product Number Product Description Technical Manual IB0110 TRβ (NR1A2) IB01101-32 Human TRβ Reporter Assay System, 3 x 32 assays in 96-well format Technical Manual IB01101 Human TRβ Reporter Assay System, 1 x 96-well format assays Technical Manual IB01102 Human TRβ Reporter Assay System, 1 x 384-well formatRead More
Evidence that diclofenac and celecoxib are thyroid hormone receptor beta antagonists
ABSTRACT Non-steroidal anti-inflammatory drugs (NSAIDS) inhibit cyclooxy- genase (COX), the enzymes that are responsible for prostaglandin production [1]. There are two isoforms, COX-1 which is constitutively expressed, and COX-2 which is inducible. NSAIDS are widely used for their analgesic, antipyretic and anti-inflammatory properties however despite their therapeutic effectiveness, their use has been widely scruti- nizedRead More
In vitro assessment of human nuclear hormone receptor activity and cytotoxicity of the fame retardant mixture FM 550 and its triarylphosphate and brominated components
ABSTRACT Firemaster®550 (FM 550) is a mixture of brominated and triarylphosphate flame retardants used in polyurethane foam-based products. The primary components are also used in numerous other applications and are thus common household and industrial contaminants. Our previous animal studiessuggested that FM 550 exposure may alter metabolism and cause weight gain. Employing human nuclear receptorRead More