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  • ABOUT
    • About INDIGO
    • Why INDIGO
    • Key Personnel
      • Board of Directors & Advisors
      • Management
    • Employment
    • INDIGO Press Releases
    • INDIGO in the News
  • ASSAYS
    • By Receptor
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      • Overview
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      • Autoimmune Disease & Inflammation
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      • Endocrinology
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      • Obesity
    • Toxicology Solutions
      • In Vitro Toxicology Platform
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    • INDIGlo Luciferase Detection Reagent
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Towards regulation of Endocrine Disrupting chemicals (EDCs) in water resources using bioassays – A guide to developing a testing strategy

ABSTRACT Endocrine disrupting chemicals (EDCs) are found in every environmental medium and are chemically diverse. Their presence in water resources can negatively impact the health of both human and wildlife. Currently, there are no mandatory screening mandates or regulations for EDC levels in complex water samples globally. Bioassays, which allow quantifying in vivo or inRead More

Filed Under: New Publications Tagged With: AR, EDC, environmental, ERa, ERb, TRa, TRb

Gene Expression: Nuclear Receptors

INTRODUCTION There are four main classes of receptors, Ion channels, G-protein coupled (GPCR), receptor tyrosine kinase and soluble (also called intracellular) receptors. The first three have ligands that are mainly present in the extracellular space (water soluble ligands). The binding of ligand causes a change in the shape/function of the protein that generates a signalRead More

Filed Under: Whitepapers Tagged With: AhR, AR, ERa, ERb, gene expression, GR, PGR, RAR, TRa, TRb, VDR

Thyroid Hormone Receptor Beta (TRβ; NR1A2)

Thyroid Hormone Receptor Beta (TRβ; NR1A2) Product Family Product Number Product Description Technical Manual IB0110 TRβ (NR1A2) IB01101-32 Human TRβ Reporter Assay System, 3 x 32 assays in 96-well format Technical Manual IB01101 Human TRβ Reporter Assay System, 1 x 96-well format assays Technical Manual IB01102 Human TRβ Reporter Assay System, 1 x 384-well formatRead More

Evidence that diclofenac and celecoxib are thyroid hormone receptor beta antagonists

ABSTRACT Non-steroidal anti-inflammatory drugs (NSAIDS) inhibit cyclooxy- genase (COX), the enzymes that are responsible for prostaglandin production [1]. There are two isoforms, COX-1 which is constitutively expressed, and COX-2 which is inducible. NSAIDS are widely used for their analgesic, antipyretic and anti-inflammatory properties however despite their therapeutic effectiveness, their use has been widely scruti- nizedRead More

Filed Under: New Publications Tagged With: TR, TRb

In vitro assessment of human nuclear hormone receptor activity and cytotoxicity of the flame retardant mixture FM 550 and its triarylphosphate and brominated components

ABSTRACT Firemaster®550 (FM 550) is a mixture of brominated and triarylphosphate flame retardants used in polyurethane foam-based products. The primary components are also used in numerous other applications and are thus common household and industrial contaminants. Our previous animal studies suggested that FM 550 exposure may alter metabolism and cause weight gain. Employing human nuclearRead More

Filed Under: New Publications Tagged With: LXR, PPAR, PPARγ, TR, TRa, TRb

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