By combining the advantages of upcyte hepatocytes with INDIGO’s industry-leading platform and science, the new hepatotoxicty assay kit helps researchers get the information they need to confidently advance their discovery processes.
INDIGO Biosciences Announces Release of Gene Expression Kit Utilizing upcyte® Hepatocytes
Portfolio Expansion Helps Researchers Move to the Next Stage of Discovery Faster State College, PA (December 5, 2018) – INDIGO Biosciences, Inc. (INDIGO), the recognized industry leader in nuclear receptor research, announced the addition of a gene expression assay kit featuring upcyte® hepatocytes to their portfolio. This addition both complements INDIGO’s industry-leading nuclear receptor assays andRead More
Comprehensive Examination of Induction of Drug Metabolizing Enzymes in Human upcyte® Hepatocytes
View Full Size Research conducted by: Samar W. Maalouf (1); John P. Vanden Heuvel (1,2); Bruce Sherf (1); &Zahidur R. Abedin (3) (1) INDIGO Biosciences, Inc., 1981 Pine Hall Road, State College, PA, USA (2) Department of Veterinary Medicine and Biomedical Sciences, 122 ASI, Penn State University, University Park, PA, USA (3) PrimBio Research Institute,Read More
Regulation of Steatosis in upcyte® Hepatocytes by Nuclear Receptor Agonists
View Full Size Research conducted by: Bruce Sherf (1); Samar W. Maalouf (1); Kaarthik John (1); Zahidur R. Abedin (1); & John P. Vanden Heuvel (1,3) (1) INDIGO Biosciences, Inc., 1981 Pine Hall Road, State College, PA, USA (2) PrimBio Research Institute, LLC, 665 Stockton Drive, STE 2001, Exton, PA, USA (Website) (3) Department ofRead More
Detection of cytokeratin 18 in proliferating, primary-like upcyte® hepatocytes to predict drug-induced hepatotoxicity
View Full Size Research conducted by: Wiebe Schaefer (1), Astrid Noerenberg (1), Adrian Kling (2), Giannella Coghlan (2), Nils Runge (1), & Timo Johannssen (1) (1) upcyte technologies GmbH, Osterfeldstr. 12-14, 22529 Hamburg, Germany (2) VLVbio AB, Hästholmsvägen 32, 13130 Nacka, Sweden Date of Publication: 2017
Use of upcyte® hepatocytes as a steatosis model on a multi-organ chip
View Full Size Research conducted by: S. Bauer (2), C. Magauer (2), I. Maschmeyer (2), C. Drewell (1), A. Lorenz (2), N. Runge (3), T. Johannssen (3), U. Marx (2), & A. Noerenberg (3) (1) Technische Universität Berlin, Medizinische Biotechnologie (2) TissUse, Berlin, Germany (3) upcyte technologies GmbH, Osterfeldstr. 12-14, D-22529 Hamburg, Germany Date of Publication: 2017
Validating the Gene Expression of Clinically Relevant CYP450 Enzymes and Transporters in Human upcyte® Hepatocytes to Develop an In Vitro Predictive Tool for DDI
View Full Size Research conducted by: Samaar Maalouf (1), Bruce Sherf(1), & Jack Vanden Huevel (1,2) (1) INDIGO Biosciences, Inc., 1981 Pine Hall Road, State College, PA, USA (2) Center for Molecular Toxicology and Carcinogenesis, 325 Life Sciences Building, Penn State University, University Park, PA 16802, USA Date of publication: 2017