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Nuclear Receptor & In Vitro Toxicology Solutions™

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  • ABOUT
    • About INDIGO
    • Why INDIGO
    • Key Personnel
      • Board of Directors & Advisors
      • Management
    • Employment
    • INDIGO Press Releases
    • INDIGO in the News
  • ASSAYS
    • By Receptor
    • By Disease State
      • Overview
      • Anemia & Kidney Disease
      • Autoimmune Disease & Inflammation
      • Cancer
      • Cardiovascular Disease
      • Diabetes
      • Endocrinology
      • NAFLD/NASH
      • Obesity
    • Toxicology Solutions
      • In Vitro Toxicology Platform
      • Gene Expression
      • MDR1 / Human P-Glycoprotein
      • Discovery Toxicology
      • Environmental Monitoring
    • INDIGlo Luciferase Detection Reagent
    • Live Cell Multiplex
    • Ortholog Assays
    • Custom Assay Development
  • TECHNOLOGY
    • Nuclear Receptor Overview
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    • Nuclear Receptor Profiling & Panels
    • Environmental Testing Solutions
    • Growth Factor Receptors
    • upcyte® Hepatocytes
    • FAQ
  • RESOURCES
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  • BLOG

Gene Expression: Nuclear Receptors

INTRODUCTION There are four main classes of receptors, Ion channels, G-protein coupled (GPCR), receptor tyrosine kinase and soluble (also called intracellular) receptors. The first three have ligands that are mainly present in the extracellular space (water soluble ligands). The binding of ligand causes a change in the shape/function of the protein that generates a signalRead More

Filed Under: Whitepapers Tagged With: AhR, AR, ERa, ERb, gene expression, GR, PGR, RAR, TRa, TRb, VDR

Nuclear Receptors Regulate Intestinal Inflammation in the Context of IBD

ABSTRACT Gastrointestinal (GI) homeostasis is strongly dependent on nuclear receptor (NR) functions. They play a variety of roles ranging from nutrient uptake, sensing of microbial metabolites, regulation of epithelial intestinal cell integrity to shaping of the intestinal immune cell repertoire. Several NRs are associated with GI pathologies; therefore, systematic analysis of NR biology, the underlyingRead More

Filed Under: New Publications Tagged With: glucocorticoids, GR, ibd, Inflammation, intestinal inflammation, nuclear receptors, PPARγ, PXR, VDR

Metadichol, A Novel ROR Gamma Inverse Agonist and Its Applications in Psoriasis

ABSTRACT Psoriasis affects 3% of the population worldwide, and there is no known cure. Psoriasis is associated with an increased risk of psoriatic arthritis, lymphomas, cardiovascular disease, and Crohn’s disease. Psoriasis treatments today include steroid and vitamin D3 cream, ultraviolet light, and immune system suppressing medications such as methotrexate. The T cells responsible for psoriasisRead More

Filed Under: New Publications Tagged With: AhR, inverse agonist, psoriasis, ROR, RORC, RORg, RORγ, TNF alpha, VDR, Vitamin D

Vitamin D Receptor (VDR; NR1I1)

Vitamin D Receptor (VDR; NR1I1) Product Family Product Number Product Description Technical Manual IB0070 VDR (NR1I1) IB00701-32 Human VDR Reporter Assay System, 3 x 32 assays in 96-well format Technical Manual IB00701 Human VDR Reporter Assay System, 1 x 96-well format assays Technical Manual IB00702 Human VDR Reporter Assay System, 1 x 384-well format assays

Profiling of vitamin D metabolic intermediates towards VDR using novel stable gene reporter cell lines IZ-VDRE and IZ-CYP24

ABSTRACT Variety of xenobiotics, including therapeutically used vitamin D analogues or environmental and alimentary endocrine disruptors, may interfere with vitamin D receptor (VDR) signalling, with serious physiological or pathophysiological consequences. Therefore, it is of topical interest to have reliable and efficient in vitro screening tool for identification of agonists and activators of human VDR. WeRead More

Filed Under: New Publications Tagged With: VDR

INDIGO Biosciences Announces NEW Vitamin D Receptor (VDR) Assay Kits and Screening Services

The Vitamin D3 Receptor (VDR) is INDIGO Biosciences newest product in the company’s variety of robust cell-based nuclear receptors; VDR is now available for our in-house screening services or as a complete cell-based INDIGO Assay Kits for your drug discovery and development research. Bring the expertise of INDIGO Biosciences into your lab using INDIGO’s robustRead More

Filed Under: press Tagged With: VDR

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