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  • HOME
  • ABOUT
    • About
    • Why INDIGO
    • Key Personnel
      • Board of Directors & Advisors
      • Management
  • PRODUCTS
    • Assays
    • Ortholog Assays
    • Growth Factor Receptors
    • In Vitro Toxicology Platform
    • MDR1 / Human P-Glycoprotein
    • Gene Expression
    • NASH Nuclear Receptors For Research
    • Disease States
    • Live Cell Multiplex
    • Custom Assay Development
  • TECHNICAL
    • Nuclear Receptor Profiling & Panels
    • Assay Kit Platform & Formats
    • FAQ
    • upcyte® Hepatocytes
    • Technical Manuals & Product Listing
    • Product Policies
    • Terms & Conditions
    • Limited Use Disclosures
  • CONTACT US
    • Contact INDIGO
    • Request Information
    • Request a Quote
    • Employment
    • Distributors
  • RESOURCES
    • Blog
    • Nuclear Receptor Resource
    • Scientific Whitepapers from INDIGO
    • New Research Publications
    • Scientific Posters
    • INDIGO Press Releases
    • INDIGO in the News

Nuclear Receptors Regulate Intestinal Inflammation in the Context of IBD

ABSTRACT Gastrointestinal (GI) homeostasis is strongly dependent on nuclear receptor (NR) functions. They play a variety of roles ranging from nutrient uptake, sensing of microbial metabolites, regulation of epithelial intestinal cell integrity to shaping of the intestinal immune cell repertoire. Several NRs are associated with GI pathologies; therefore, systematic analysis of NR biology, the underlyingRead More

Filed Under: New Publications Tagged With: glucocorticoids, GR, ibd, Inflammation, intestinal inflammation, nuclear receptors, PPARγ, PXR, VDR

Metadichol® A Novel Inverse Agonist of Thyroid Receptor and its Application in Thyroid Diseases

ABSTRACT An estimated 200 million individuals worldwide have a thyroid disorder. Thyroid diseases affect seven times more women than men. People not diagnosed make up the majority of thyroid patients. There is a need to find novel and safe ways to change the underlying disease processes, rather than merely stop excess thyroid hormone production asRead More

Filed Under: New Publications Tagged With: Grave's disease, hashimoto, hyperthyroidism, hypothyroidism, Metadichol, nano emulsion, thyroid hormone, TR alpha, TR beta, VDR

Metadichol, A Novel ROR Gamma Inverse Agonist and Its Applications in Psoriasis

ABSTRACT Psoriasis affects 3% of the population worldwide, and there is no known cure. Psoriasis is associated with an increased risk of psoriatic arthritis, lymphomas, cardiovascular disease, and Crohn’s disease. Psoriasis treatments today include steroid and vitamin D3 cream, ultraviolet light, and immune system suppressing medications such as methotrexate. The T cells responsible for psoriasisRead More

Filed Under: New Publications Tagged With: AhR, inverse agonist, psoriasis, ROR, RORC, RORg, RORγ, TNF alpha, VDR, Vitamin D

Profiling of vitamin D metabolic intermediates towards VDR using novel stable gene reporter cell lines IZ-VDRE and IZ-CYP24

ABSTRACT Variety of xenobiotics, including therapeutically used vitamin D analogues or environmental and alimentary endocrine disruptors, may interfere with vitamin D receptor (VDR) signalling, with serious physiological or pathophysiological consequences. Therefore, it is of topical interest to have reliable and efficient in vitro screening tool for identification of agonists and activators of human VDR. WeRead More

Filed Under: New Publications Tagged With: VDR

INDIGO Biosciences Announces NEW Vitamin D Receptor (VDR) Assay Kits and Screening Services

The Vitamin D3 Receptor (VDR) is INDIGO Biosciences newest product in the company’s variety of robust cell-based nuclear receptors; VDR is now available for our in-house screening services or as a complete cell-based INDIGO Assay Kits for your drug discovery and development research. Bring the expertise of INDIGO Biosciences into your lab using INDIGO’s robustRead More

Filed Under: press Tagged With: VDR

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