Luteolin is a dietary flavonoid with medicinal properties including antioxidant, antimicrobial, anticancer, antiallergic, and anti-inflammatory. However, the effect of luteolin on liver X receptors (LXRs), oxysterol sensors that regulate cholesterol homeostasis, lipogenesis, and inflammation, has yet to be studied. To unveil the potential of luteolin as an LXRα/β modulator, we investigated by real-time RT-PCR the expression of LXR-target genes, namely, sterol regulatory element binding protein 1c (SREBP-1c) in hepatocytes and ATP-binding cassette transporter (ABC)A1 in macrophages.
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Date of publication: 02 May 2016; Journal of Natural Products
Author information: Vera Francisco (1,2); Artur Figueirinha (1,3); Gustavo Costa (1,3); Joana Liberal (1,2); Isabel Ferreira (2); Maria C. Lopes (1,3); Carmen García-Rodríguez (4); Maria T. Cruz (1,3); & Maria T. Batista (1,2,3)
(1) Center for Neurosciences and Cell Biology, University of Coimbra, 3000-214 Coimbra, Portugal
(2) Center for Pharmaceutical Studies, Faculty of Pharmacy, University of Coimbra, Pólo das Ciências da Saúde, Azinhaga de Santa Comba, 3000-548 Coimbra, Portugal
(3) Faculty of Pharmacy, University of Coimbra, Pólo das Ciências da Saúde, Azinhaga de Santa Comba, 3000-548 Coimbra, Portugal
(4) Instituto de Biología y Genética Molecular, Universidad de Valladolid−CSIC, C/Sanz y Forés 3, 47003 Valladolid, Spain