FXR is a nuclear receptor that has gained a great deal of interest in terms of its biological role and potential as therapeutic target. Activating FXR increases transcription of genes that are geared toward preventing synthesis and uptake and promoting excretion of bile acids. One effect of FXR activation is decreased expression of Cyp7A1 and thus bile acid synthesis; this is accomplished through induction of SHP (short heterodimer partner) which then represses Cyp7A1 transcription.
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Date of publication: 11 March 2006
Author information: Jerry Thompson (1); Jun Zhang (1); & Jack Vanden Heuvel, PhD (1,2)
(1) Center for Nutrigenomics, Penn State University, University Park, PA
(2) INDIGO Biosciences, Inc., State College, PA