INDIGO Blog

View our most recent posts to learn more about various types of receptors, cell-based assays, and their use in drug discovery and environmental testing applications. 

 

Hepatocyte Nuclear Factor 4 Alpha in Disease and Drug Discovery

The Hepatocyte Nuclear Factor 4 Alpha (HNF4α) What is the Hepatocyte Nuclear Factor 4 Alpha (HNF4α)? The Hepatocyte Nuclear Factor 4 Alpha (HNF4a) belongs to the nuclear receptor superfamily, serving as a critical transcription factor involved in the regulation of gene expression in various tissues, particularly the liver, pancreas, kidney, and intestine. As a master…

Understanding Assay Performance Metrics

Nuclear Receptors and Cancer Research: Current Trends and Applications When embarking on the search for a reliable cell-based assay, it’s common practice to start by typing “Receptor X cell-based assay” into the search bar of your preferred internet browser. From there, you navigate through the multitude of search results, sifting through the information provided. This…

Oxytocin Receptor in Disease and Drug Discovery

Nuclear Receptors and Cancer Research: Current Trends and Applications The Oxytocin Receptor (OXTR) What is the Oxytocin Receptor (OXTR)? The Oxytocin Receptor (OXTR) is a vital component of the human body’s neuroendocrine system, primarily associated with social behavior, reproductive functions, and emotional regulation. The Oxytocin Receptor belongs to the G protein-coupled receptor (GPCR) family, playing…

Alpha-1 Adrenergic Receptors in Disease and Drug Discovery

Nuclear Receptors and Cancer Research: Current Trends and Applications Adrenergic receptors, a class of G protein-coupled receptors (GPCRs), play a pivotal role in mediating the physiological effects of the sympathetic nervous system which is responsible for “fight-or-flight” response. These receptors are integral components of the human body’s response to stress, regulating a multitude of functions…

Adrenergic Receptors In Disease and Drug Discovery

Nuclear Receptors and Cancer Research: Current Trends and Applications Adrenergic receptors, a class of G protein-coupled receptors (GPCRs), play a pivotal role in mediating the physiological effects of the sympathetic nervous system which is responsible for the “fight-or-flight” response. These receptors are integral components of the human body’s response to stress, regulating a multitude of…