INDIGO Blog

View our most recent posts to learn more about various types of receptors, cell-based assays, and their use in drug discovery and environmental testing applications. 

 

Best Practices for Reporter Assay Method Transfer in CRO Workflows

Contract Research Organizations (CROs) are often asked to do more than simply run assays. They are expected to reproduce client methods, maintain data continuity across teams and sites, meet aggressive timelines, and support programs that may move quickly from exploratory screening to regulated or decision-driving studies. In that environment, assay transfer, sometimes referred to as…

Bradykinin Receptors B1R and B2R in Disease Research and Drug Discovery

Bradykinin receptors B1R and B2R are G protein-coupled receptors (GPCRs) that play roles in inflammation, vascular biology, pain signaling, and tissue injury responses. As key components of the kallikrein-kinin system, the Bradykinin receptors translate bradykinin-family peptide activity into cellular responses that influence vascular permeability, smooth muscle tone, immune cell activation, and nociception. Their distinct expression…

Characterizing PFAS Compounds Using Human Cell-Based Bioassays

Per- and polyfluoroalkyl substances (PFAS) are no longer viewed as a small set of well-known legacy contaminants. They represent a large, structurally diverse chemical class that includes long- and short-chain compounds, replacement chemistries, precursors, degradation products, and complex environmental mixtures.For researchers characterizing PFAS compounds, the challenge is no longer simply determining whether a compound is…

Why AhR Testing Matters for Safer Crop Protection Products

Bringing a new crop protection product to market takes more than proving efficacy. Today’s agricultural innovators are under growing pressure to identify potential safety concerns earlier, generate stronger mechanistic data, and make smarter development decisions before costly downstream studies begin.That shift is changing how R&D teams think about screening. In addition to evaluating on-target performance,…

Mechanistic Toxicology Assays: How Cell-based Tools Reveal Mode of Action Insights

Understanding the mechanism of toxicity is essential across the chemical and biomedical sciences. Whether in drug discovery, safety assessment, or environmental evaluation, mechanistic insight provides the foundation for interpreting biological effects in a meaningful way. By defining how a chemical perturbs specific pathways, researchers can identify structure-activity relationships, compare responses across compound classes, and design…