INDIGO Blog

View our most recent posts to learn more about various types of receptors, cell-based assays, and their use in drug discovery and environmental testing applications. 

 

The c-Met Receptor (HGFR) in Disease and Drug Discovery

What is the c-Met Receptor (HGFR)? The c-Met receptor, also known as hepatocyte growth factor receptor (HGFR), stands as a pivotal receptor tyrosine kinase involved in various cellular processes such as proliferation, survival, migration, and tissue regeneration. A transmembrane protein on the surface of diverse cell types like epithelial and endothelial cells, c-Met mediates the…

Taming Standard Deviation in Cell-based Assays

Cell-based assays can be used for a wide variety of applications ranging from preclinical drug discovery to testing for environmental contaminants in water, but navigating the maze of potential user pitfalls is essential to obtain precise and reliable data! This blog post explores tips and tricks to help you master cell-based assay procedures-from optimizing user…

Hepatocyte Nuclear Factor 4 Alpha in Disease and Drug Discovery

The Hepatocyte Nuclear Factor 4 Alpha (HNF4α) What is the Hepatocyte Nuclear Factor 4 Alpha (HNF4α)? The Hepatocyte Nuclear Factor 4 Alpha (HNF4a) belongs to the nuclear receptor superfamily, serving as a critical transcription factor involved in the regulation of gene expression in various tissues, particularly the liver, pancreas, kidney, and intestine. As a master…

Understanding Assay Performance Metrics

Nuclear Receptors and Cancer Research: Current Trends and Applications When embarking on the search for a reliable cell-based assay, it’s common practice to start by typing “Receptor X cell-based assay” into the search bar of your preferred internet browser. From there, you navigate through the multitude of search results, sifting through the information provided. This…

Oxytocin Receptor in Disease and Drug Discovery

Nuclear Receptors and Cancer Research: Current Trends and Applications The Oxytocin Receptor (OXTR) What is the Oxytocin Receptor (OXTR)? The Oxytocin Receptor (OXTR) is a vital component of the human body’s neuroendocrine system, primarily associated with social behavior, reproductive functions, and emotional regulation. The Oxytocin Receptor belongs to the G protein-coupled receptor (GPCR) family, playing…