Nuclear Receptor Disease State Targets

Supercharge your drug discovery and development with INDIGO Biosciences' cell-based assays. Gain deep insights by unlocking the potential of multi-target interactions for enhanced therapeutic efficacy. Transform your research today!

Unlock the power of polypharmacology with INDIGO Biosciences' advanced solutions and revolutionize your drug discovery efforts.

Target specific disease mechanisms with precision and effectiveness
Get holistic evaluation for enhanced compound efficacy and safety
Maximize therapeutic potential by targeting multiple pathways simultaneously

Review Various Disease States and their Receptors

Anemia & Kidney Disease

Autoimmune Disease & Inflammation

Cancer

Cardiovascular Disease

Diabetes

Endocrinology

NAFLD/NASH

Obesity

Harness Polypharmacology to Improve the Potential for Clinical Efficacy

Advances in systems biology are revealing a phenotypic robustness and a network structure that strongly suggests that exquisitely selective compounds, compared with multi-target drugs, may exhibit lower than desired clinical efficacy. This new appreciation of the role of polypharmacology has significant implications for the two major sources of attrition in drug development, efficacy, and toxicity. Thus defining the biological niche of each receptor as well as understanding overlapping pathways and functions provides valuable context for evaluating a compound’s liabilities and promise.

Defining the system that each receptor participates in can be approached in several ways, such as sequence similarity, potential disease implication, or transcriptional networks. By choosing a select group of receptors to study based on disease state, it is possible to better understand the biological effects of your compounds. With INDIGO's extensive portfolio of receptor assays, you can design your own panel based on a disease state or talk to our experts to assist in developing a plan of study.

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Applications for INDIGO’s Luciferase Reporter Assays

Drug Discovery

Rapidly evaluate the efficacy and safety profile of a drug candidate with INDIGO’s Reporter Assay Services and streamline the development process to safer, more effective pharmaceutical agents.

Environmental Testing

Effectively screen environmental samples, with INDIGO’s Reporter Assay Services and actively contribute to building a safer environment.

Disease State Targets

Quickly gain insights into the mechanisms underlying the involvement of key receptors in various diseases with INDIGO’s Reporter Assay Services.

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What Our Customers Say

"I think if we had gone with anyone else, we would still be running assays rather than having confidence in the data that we've gained with INDIGO."

Mark

Principal Scientist

"The fact that they do have this comprehensive panel…essentially you can pick and choose which of the members of the panel you want to run."

Linda

Scientist

"The overall experience went smoothly, and I got valuable data that helped me advance several molecules through the discovery pipeline."