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  • PRODUCTS
    • Assay Kit Platform & Formats
    • All Assays
    • Growth Factor Assays
    • Toxicology Assays
      • In Vitro Hepatotoxicity Assay Kit
      • Gene Expression Profiling Assay Kit
      • P-gp/MDR1 Drug Interaction Assay Kit
    • Environmental Monitoring Assays
    • Ortholog Receptor Assays
    • INDIGlo Luciferase Detection Reagent
    • Live Cell Multiplex
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    • Reporter Assay Services
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    • Custom Assay Development
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      • Autoimmune Disease & Inflammation
      • Cancer
      • Cardiovascular Disease
      • Diabetes
      • Endocrinology
      • NAFLD/NASH
      • Obesity
    • Environmental Monitoring
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      • Webinars from INDIGO
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Nuclear Receptor Disease State

INDIGO Biosciences offers a comprehensive portfolio of cell-based luciferase reporter assays, ideally suited for examining receptor selectivity and potential off-target effects. INDIGO’s assays have been demonstrated to provide fast, accurate, reproducible results. In addition to human receptor assays, INDIGO also offers more than 40 ortholog assays across multiple species for use in prospective and retrospective screening of animal models. Check out our list of available receptors based on the functional areas where they work and their potential disease indicators.

Disease StateNuclear Receptors
Alzheimer's DiseaseERα (NR3A1); ERβ (NR3A2); ERRγ (NR3B3)
AtherosclerosisLXRα (NR1H3); LXRβ (NR1H2); Nf-kB; PPARα (NR1C1); RORα (NR1F1)
Autoimmune DiseasesAR (NR3C4); AhR; ERα (NR3A1); ERβ (NR3A2); GR (NR3C1); MR (NR3C2); NFAT; PGR (NR3C3); PPARα (NR1C1); PPARγ (NR1C3); RARα (NR1B1); RARβ (NR1B2); RARγ (NR1B3); RORα (NR1F1); RORγ (NR1F3); RXRα (NR2B1); RXRβ (NR2B2); RXRγ (NR2B3); TEAD4/YAP; VDR (NR1I1)
Bile Acid & Xenobiotic MetabolismAhR; CAR (NR1I3); EGFR1; FXR (NR1H4); LRH-1 (NR5A2); PXR (NR1I2); RORγ (NR1F3); VDR (NR1I1)
CancerAR (NR3C4); CB1R;EGFR1; EPOR; ERα (NR3A1); ERβ (NR3A2); ERRγ (NR3B3); FGFR1/2; GHR; LRH-1 (NR5A2); Nf-kB; NFAT; Nrf2; PPARδ (NR1C2); PPARγ (NR1C3); RARα (NR1B1); RARβ (NR1B2); RARγ (NR1B3); RXRα (NR2B1); RXRβ (NR2B2); RXRγ (NR2B3);TEAD4/YAP; TGFβR; TPOR; VDR (NR1I1); VEGFR2
Cardiovascular DiseaseCB1R; EPOR; ERα (NR3A1); ERβ (NR3A2); ERRγ (NR3B3); FGFR1/β-Klotho; GHR; TEAD4/YAP; TGFβR; VEGFR2
Circadian RhythmERRα (NR3B1); RORα (NR1F1); RORγ (NR1F3); TRα (NR1A1); TRβ (NR1A2); VEGFR2
CNS, Circadian, & Basal MetabolismEPOR; LXRβ (NR1H2); MR (NR3C2); NFAT; RARβ (NR1B2); RORα (NR1F1); RORγ (NR1F3); RXRβ (NR2B2); TRα (NR1A1); TRβ (NR1A2);
DiabetesCB1R; EGFR1; FGFR/β-Klotho; GHR; GR (NR3C1); LXRα (NR1H3); LXRβ (NR1H2); PPARγ (NR1C3); RXRα (NR2B1); RXRβ (NR2B2); RXRγ (NR2B3); TGFβR
Drug-Drug InteractionsAhR; CAR (NR1I3); FXR (NR1H4); LRH-1 (NR5A2); LXRα (NR1H3); Nrf2; PPARα (NR1C1); PXR (NR1I2); VDR (NR1I1)
Drug-Nutrient InteractionAhR; CAR-2 (NR1I3i2); CAR-3 (NR1I3i3); FXR (NR1H4); Nrf2; PXR (NR1I2); VDR (NR1I1)
DyslipidemiaFXR (NR1H4); LRH-1 (NR5A2); LXRα (NR1H3); LXRβ (NR1H2); PPARα (NR1C1); RORα (NR1F1); TRα (NR1A1); TRβ (NR1A2); VDR (NR1I1)
EndocrinologyAR (NR3C4); ERα (NR3A1); ERβ (NR3A2); ERRγ (NR3B3); MR (NR3C2); PGR (NR3C3)
Environmental ToxicologyAR (NR3C4); AhR; ERα (NR3A1); ERβ (NR3A2); ERRα (NR3B1); ERRγ (NR3B3); Nrf2; PPARγ (NR1C3); PGR (NR3C3); TRα (NR1A1); TRβ (NR1A2)
FertilityEPOR; ERα (NR3A1); ERRγ (NR3B3)
InflammationCB1R; EGFR1; FGFR1/β-Klotho; GHR; GR (NR3C1); Nf-kB; NFAT; Nrf2; PPARα (NR1C1); PPARδ (NR1C2); PPARγ (NR1C3); RORα (NR1F1); RORγ (NR1F3); TGFβR
Lipid Metabolism & EnergyCB1R; ERRα (NR3B1); FGFR1/β-Klotho; GR (NR3C1); LXRα (NR1H3); PPARα (NR1C1); PPARδ (NR1C2); PPARγ (NR1C3); TRβ (NR1A2)
Metabolic DiseaseFGFR1/β-Klotho; FXR (NR1H4); GHR; GR (NR3C1); LRH-1 (NR5A2); LXRα (NR1H3); LXRβ (NR1H2); PPARα (NR1C1); PPARδ (NR1C2); PPARγ (NR1C3); TRα (NR1A1); VDR (NR1I1)
NAFLD/NASHCAR (NR1I3); FGFR1/β-Klotho; FXR (NR1H4); LXRα (NR1H3); LXRβ (NR1H2); PPARα (NR1C1); PPARδ (NR1C2); PPARγ (NR1C3); PXR (NR1I2); RARα (NR1B1); RARβ (NR1B2); RORγ (NR1F3); TRα (NR1A1); VDR (NR1I1)
ObesityCB1R; ERβ (NR3A2); FGFR1/β-Klotho; GHR; GR (NR3C1); PPARδ (NR1C2); PPARγ (NR1C3); TGFβR; TRα (NR1A1); TRβ (NR1A2)
OsteoporosisAR (NR3C4); ERα (NR3A1); ERβ (NR3A2); ERRα (NR3B1); ERRγ (NR3B3); GHR; PGR (NR3C3); VDR (NR1I1)
PsoriasisRARα (NR1B1); RARβ (NR1B2); RARγ (NR1B3); RXRα (NR2B1); RXRβ (NR2B2); RXRγ (NR2B3); VDR (NR1I1)
Reproduction & DevelopmentAR (NR3C4); CB1R; ERα (NR3A1); ERβ (NR3A2); ERRγ (NR3B3); FGFR1/2; GHR; NFAT; PGR (NR3C3); RARα (NR1B1); RARγ (NR1B3); RXRα (NR2B1); RXRγ (NR2B3); TEAD4/YAP
Retinoid PanelRARα (NR1B1); RARβ (NR1B2); RARγ (NR1B3); RORα (NR1F1); RORγ (NR1F3); RXRα (NR2B1); RXRβ (NR2B2); RXRγ (NR2B3)
Steroid ReceptorAR (NR3C4); ERα (NR3A1); ERβ (NR3A2); ERRγ (NR3B3); GR (NR3C1); MR (NR3C2); PGR (NR3C3)
SteroidogenesisLRH-1 (NR5A2)
ToxicologyAhR; CAR (NR1I3); FXR (NR1H4); Nf-kB; Nrf2; PPARα (NR1C1); TRα (NR1A1)
Wound HealingAR (NR3C4); EGFR1; ERα (NR3A1); ERβ (NR3A2); FGFR1/2; PPARδ (NR1C2); PXR (NR1I2); RARα (NR1B1); RARβ (NR1B2); RARγ (NR1B3); RXRα (NR2B1); RXRβ (NR2B2); RXRγ (NR2B3); TGFβR
Xenobiotic MetabolismAhR; CAR (NR1I3); Nrf2;PXR (NR1I2)
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