Nuclear Receptor Disease State

INDIGO Biosciences offers a comprehensive portfolio of cell-based luciferase reporter assays, ideally suited for examining receptor selectivity and potential off-target effects. INDIGO’s assays have been demonstrated to provide fast, accurate, reproducible results. In addition to human receptor assays, INDIGO also offers more than 40 ortholog assays across multiple species for use in prospective and retrospective screening of animal models. Check out our list of available receptors based on the functional areas where they work and their potential disease indicators.

Disease State	Nuclear Receptors
Alzheimer's Disease	ERα (NR3A1); ERβ (NR3A2); ERRγ (NR3B3)
Atherosclerosis	LXRα (NR1H3); LXRβ (NR1H2); Nf-kB; PPARα (NR1C1); RORα (NR1F1)
Autoimmune Diseases	AR (NR3C4); AhR; ERα (NR3A1); ERβ (NR3A2); GR (NR3C1); MR (NR3C2); NFAT; PGR (NR3C3); PPARα (NR1C1); PPARγ (NR1C3); RARα (NR1B1); RARβ (NR1B2); RARγ (NR1B3); RORα (NR1F1); RORγ (NR1F3); RXRα (NR2B1); RXRβ (NR2B2); RXRγ (NR2B3); TEAD4/YAP; VDR (NR1I1)
Bile Acid & Xenobiotic Metabolism	AhR; CAR (NR1I3); EGFR1; FXR (NR1H4); LRH-1 (NR5A2); PXR (NR1I2); RORγ (NR1F3); VDR (NR1I1)
Cancer	AR (NR3C4); CB1R;EGFR1; EPOR; ERα (NR3A1); ERβ (NR3A2); ERRγ (NR3B3); FGFR1/2; GHR; LRH-1 (NR5A2); Nf-kB; NFAT; Nrf2; PPARδ (NR1C2); PPARγ (NR1C3); RARα (NR1B1); RARβ (NR1B2); RARγ (NR1B3); RXRα (NR2B1); RXRβ (NR2B2); RXRγ (NR2B3);TEAD4/YAP; TGFβR; TPOR; VDR (NR1I1); VEGFR2
Cardiovascular Disease	CB1R; EPOR; ERα (NR3A1); ERβ (NR3A2); ERRγ (NR3B3); FGFR1/β-Klotho; GHR; TEAD4/YAP; TGFβR; VEGFR2
Circadian Rhythm	ERRα (NR3B1); RORα (NR1F1); RORγ (NR1F3); TRα (NR1A1); TRβ (NR1A2); VEGFR2
CNS, Circadian, & Basal Metabolism	EPOR; LXRβ (NR1H2); MR (NR3C2); NFAT; RARβ (NR1B2); RORα (NR1F1); RORγ (NR1F3); RXRβ (NR2B2); TRα (NR1A1); TRβ (NR1A2);
Diabetes	CB1R; EGFR1; FGFR/β-Klotho; GHR; GR (NR3C1); LXRα (NR1H3); LXRβ (NR1H2); PPARγ (NR1C3); RXRα (NR2B1); RXRβ (NR2B2); RXRγ (NR2B3); TGFβR
Drug-Drug Interactions	AhR; CAR (NR1I3); FXR (NR1H4); LRH-1 (NR5A2); LXRα (NR1H3); Nrf2; PPARα (NR1C1); PXR (NR1I2); VDR (NR1I1)
Drug-Nutrient Interaction	AhR; CAR-2 (NR1I3i2); CAR-3 (NR1I3i3); FXR (NR1H4); Nrf2; PXR (NR1I2); VDR (NR1I1)
Dyslipidemia	FXR (NR1H4); LRH-1 (NR5A2); LXRα (NR1H3); LXRβ (NR1H2); PPARα (NR1C1); RORα (NR1F1); TRα (NR1A1); TRβ (NR1A2); VDR (NR1I1)
Endocrinology	AR (NR3C4); ERα (NR3A1); ERβ (NR3A2); ERRγ (NR3B3); MR (NR3C2); PGR (NR3C3)
Environmental Toxicology	AR (NR3C4); AhR; ERα (NR3A1); ERβ (NR3A2); ERRα (NR3B1); ERRγ (NR3B3); Nrf2; PPARγ (NR1C3); PGR (NR3C3); TRα (NR1A1); TRβ (NR1A2)
Fertility	EPOR; ERα (NR3A1); ERRγ (NR3B3)
Inflammation	CB1R; EGFR1; FGFR1/β-Klotho; GHR; GR (NR3C1); Nf-kB; NFAT; Nrf2; PPARα (NR1C1); PPARδ (NR1C2); PPARγ (NR1C3); RORα (NR1F1); RORγ (NR1F3); TGFβR
Lipid Metabolism & Energy	CB1R; ERRα (NR3B1); FGFR1/β-Klotho; GR (NR3C1); LXRα (NR1H3); PPARα (NR1C1); PPARδ (NR1C2); PPARγ (NR1C3); TRβ (NR1A2)
Metabolic Disease	FGFR1/β-Klotho; FXR (NR1H4); GHR; GR (NR3C1); LRH-1 (NR5A2); LXRα (NR1H3); LXRβ (NR1H2); PPARα (NR1C1); PPARδ (NR1C2); PPARγ (NR1C3); TRα (NR1A1); VDR (NR1I1)
NAFLD/NASH	CAR (NR1I3); FGFR1/β-Klotho; FXR (NR1H4); LXRα (NR1H3); LXRβ (NR1H2); PPARα (NR1C1); PPARδ (NR1C2); PPARγ (NR1C3); PXR (NR1I2); RARα (NR1B1); RARβ (NR1B2); RORγ (NR1F3); TRα (NR1A1); VDR (NR1I1)
Obesity	CB1R; ERβ (NR3A2); FGFR1/β-Klotho; GHR; GR (NR3C1); PPARδ (NR1C2); PPARγ (NR1C3); TGFβR; TRα (NR1A1); TRβ (NR1A2)
Osteoporosis	AR (NR3C4); ERα (NR3A1); ERβ (NR3A2); ERRα (NR3B1); ERRγ (NR3B3); GHR; PGR (NR3C3); VDR (NR1I1)
Psoriasis	RARα (NR1B1); RARβ (NR1B2); RARγ (NR1B3); RXRα (NR2B1); RXRβ (NR2B2); RXRγ (NR2B3); VDR (NR1I1)
Reproduction & Development	AR (NR3C4); CB1R; ERα (NR3A1); ERβ (NR3A2); ERRγ (NR3B3); FGFR1/2; GHR; NFAT; PGR (NR3C3); RARα (NR1B1); RARγ (NR1B3); RXRα (NR2B1); RXRγ (NR2B3); TEAD4/YAP
Retinoid Panel	RARα (NR1B1); RARβ (NR1B2); RARγ (NR1B3); RORα (NR1F1); RORγ (NR1F3); RXRα (NR2B1); RXRβ (NR2B2); RXRγ (NR2B3)
Steroid Receptor	AR (NR3C4); ERα (NR3A1); ERβ (NR3A2); ERRγ (NR3B3); GR (NR3C1); MR (NR3C2); PGR (NR3C3)
Steroidogenesis	LRH-1 (NR5A2)
Toxicology	AhR; CAR (NR1I3); FXR (NR1H4); Nf-kB; Nrf2; PPARα (NR1C1); TRα (NR1A1)
Wound Healing	AR (NR3C4); EGFR1; ERα (NR3A1); ERβ (NR3A2); FGFR1/2; PPARδ (NR1C2); PXR (NR1I2); RARα (NR1B1); RARβ (NR1B2); RARγ (NR1B3); RXRα (NR2B1); RXRβ (NR2B2); RXRγ (NR2B3); TGFβR
Xenobiotic Metabolism	AhR; CAR (NR1I3); Nrf2;PXR (NR1I2)