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  • HOME
  • ABOUT
    • About
    • Why INDIGO
    • Key Personnel
      • Board of Directors & Advisors
      • Management
  • PRODUCTS
    • Assays
    • Ortholog Assays
    • Growth Factor Receptors
    • In Vitro Toxicology Platform
    • MDR1 / Human P-Glycoprotein
    • Gene Expression
    • NASH Nuclear Receptors For Research
    • Disease States
    • Live Cell Multiplex
    • Custom Assay Development
  • TECHNICAL
    • Nuclear Receptor Profiling & Panels
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Nuclear Receptor Disease State Affiliations

Disease StateNuclear Receptors
Alzheimer's DiseaseERα (NR3A1); ERβ (NR3A2); ERRγ (NR3B3)
AtherosclerosisLXRα (NR1H3); LXRβ (NR1H2); Nf-kB; PPARα (NR1C1); RORα (NR1F1)
Autoimmune DiseasesAR (NR3C4); AhR; ERα (NR3A1); ERβ (NR3A2); GR (NR3C1); MR (NR3C2); NFAT; PGR (NR3C3); PPARα (NR1C1); PPARγ (NR1C3); RARα (NR1B1); RARβ (NR1B2); RARγ (NR1B3); RORα (NR1F1); RORγ (NR1F3); RXRα (NR2B1); RXRβ (NR2B2); RXRγ (NR2B3); TEAD4/YAP; VDR (NR1I1)
Bile Acid & Xenobiotic MetabolismAhR; CAR (NR1I3); EGFR1; FXR (NR1H4); RORγ (NR1F3); PXR (NR1I2); LRH-1 (NR5A2); VDR (NR1I1)
CancerNFAT, PPARδ (NR1C2); PPARγ (NR1C3); ERα (NR3A1); ERβ (NR3A2); VDR (NR1I1); RXRα (NR2B1); RXRβ (NR2B2); RXRγ (NR2B3); RARα (NR1B1); RARβ (NR1B2); RARγ (NR1B3); AR (NR3C4); EGFR1; ERRγ (NR3B3); GHR; Nf-kB; Nrf2; LRH-1 (NR5A2); TEAD4/YAP; TGFβR; VEGFR2
Cardiovascular DiseaseERα (NR3A1); ERβ (NR3A2); ERRγ (NR3B3); GHR; TEAD4/YAP; TGFβR; VEGFR2
Circadian RhythmTRα (NR1A1); TRβ (NR1A2); RORα (NR1F1); RORγ (NR1F3); ERRα (NR3B1); VEGFR2
CNS, Circadian, & Basal MetabolismLXRβ (NR1H2); MR (NR3C2); NFAT; RXRβ (NR2B2); TRα (NR1A1); TRβ (NR1A2); RARβ (NR1B2); RORα (NR1F1); RORγ (NR1F3)
DiabetesEGFR1; PPARγ (NR1C3); GHR; GR (NR3C1); LXRα (NR1H3); LXRβ (NR1H2); RXRα (NR2B1); RXRβ (NR2B2); RXRγ (NR2B3); TGFβR
Drug-Drug InteractionsAhR; CAR (NR1I3); FXR (NR1H4); LRH-1 (NR5A2); LXRα (NR1H3); Nrf2; PPARα (NR1C1); PXR (NR1I2); VDR (NR1I1)
Drug-Nutrient InteractionAhR; CAR-2 (NR1I3i2); CAR-3 (NR1I3i3); FXR (NR1H4); Nrf2; PXR (NR1I2); VDR (NR1I1)
DyslipidemiaPPARα (NR1C1); LXRα (NR1H3); LXRβ (NR1H2); FXR (NR1H4); VDR (NR1I1); TRα (NR1A1); TRβ (NR1A2); RORα (NR1F1); LRH-1 (NR5A2)
EndocrinologyERα (NR3A1); ERβ (NR3A2); MR (NR3C2); AR (NR3C4); PGR (NR3C3); ERRγ (NR3B3)
Environmental ToxicologyAR (NR3C4); AhR; ERα (NR3A1); ERβ (NR3A2); ERRα (NR3B1); ERRγ (NR3B3); Nrf2; PPARγ (NR1C3); PGR (NR3C3); TRα (NR1A1); TRβ (NR1A2)
FertilityERα (NR3A1); ERRγ (NR3B3)
InflammationEGFR1; NFAT; PPARα (NR1C1); PPARδ (NR1C2); PPARγ (NR1C3); GHR; GR (NR3C1); RORα (NR1F1); RORγ (NR1F3); Nf-kB; Nrf2; TGFβR
Lipid Metabolism & EnergyPPARα (NR1C1); PPARδ (NR1C2); PPARγ (NR1C3); GR (NR3C1); LXRα (NR1H3); TRβ (NR1A2); ERRα (NR3B1)
Metabolic DiseasePPARα (NR1C1); PPARδ (NR1C2); PPARγ (NR1C3); GHR; GR (NR3C1); LXRα (NR1H3); LXRβ (NR1H2); FXR (NR1H4); VDR (NR1I1); TRα (NR1A1); LRH-1 (NR5A2)
NAFLD/NASHPPARα (NR1C1); PPARγ (NR1C3); PPARδ (NR1C2); FXR (NR1H4); LXRα (NR1H3); LXRβ (NR1H2); VDR (NR1I1); PXR (NR1I2); CAR (NR1I3); TRα (NR1A1); RARα (NR1B1); RARβ (NR1B2); RORγ (NR1F3)
ObesityPPARδ (NR1C2); PPARγ (NR1C3); GR (NR3C1); ERβ (NR3A2); GHR; TRα (NR1A1); TRβ (NR1A2); TGFβR
OsteoporosisERα (NR3A1); ERβ (NR3A2); GHR; VDR (NR1I1); AR (NR3C4); PGR (NR3C3); ERRα (NR3B1); ERRγ (NR3B3)
PsoriasisVDR (NR1I1); RXRα (NR2B1); RXRβ (NR2B2); RXRγ (NR2B3); RARα (NR1B1); RARβ (NR1B2); RARγ (NR1B3)
Reproduction & DevelopmentERα (NR3A1); ERβ (NR3A2); NFAT; RXRα (NR2B1); RXRγ (NR2B3); RARα (NR1B1); RARγ (NR1B3); AR (NR3C4); PGR (NR3C3); ERRγ (NR3B3); GHR; TEAD4/YAP
Retinoid PanelRXRα (NR2B1); RXRβ (NR2B2); RXRγ (NR2B3); RARα (NR1B1); RARβ (NR1B2); RARγ (NR1B3); RORα (NR1F1); RORγ (NR1F3)
Steroid ReceptorGR (NR3C1); ERα (NR3A1); ERβ (NR3A2); MR (NR3C2); AR (NR3C4); PGR (NR3C3); ERRγ (NR3B3)
SteroidogenesisLRH-1 (NR5A2)
ToxicologyPPARα (NR1C1); FXR (NR1H4); CAR (NR1I3); TRα (NR1A1); AhR; Nf-kB; Nrf2
Wound HealingAR (NR3C4); EGFR1; ERα (NR3A1); ERβ (NR3A2); PPARδ (NR1C2); PXR (NR1I2); RARα (NR1B1); RARβ (NR1B2); RARγ (NR1B3); RXRα (NR2B1); RXRβ (NR2B2); RXRγ (NR2B3); TGFβR
Xenobiotic MetabolismCAR (NR1I3); PXR (NR1I2); AhR; Nrf2
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