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Targeted Gene Expression for Mechanistic Follow-Up
When an initial assay reveals a biological signal, the next step is understanding what that signal means. INDIGO’s Gene Expression Services provide focused follow-up in relevant cell systems to help researchers confirm pathway activity, assess cellular response, and generate mechanistic insight.
Focused Gene Expression Data for Better Biological Decisions
Not every important safety marker appears first as overt toxicity or a simple change in viability. In many studies, the most useful next step is targeted gene expression analysis that helps confirm whether a pathway is engaged, whether a specific cellular response is occurring, or whether a functional assay result is supported by orthogonal evidence.
INDIGO’s Gene Expression Services are designed for this stage of research. This service is best suited for researchers who already have a biological question and need focused data to guide the next decision.
Why Choose INDIGO’s Gene Expression Services?
Built for Mechanistic Follow-Up
Designed to help move from an observed signal to a more informed biological interpretation.
Relevant Cell-Based Context
Studies can be performed in biologically appropriate in vitro systems based on the question being asked.
Well Suited for Orthogonal Support
Gene expression can add a second layer of evidence after reporter assay, pathway, or other functional results.
Targeted Rather Than Overbuilt
Ideal for focused follow-up studies when broad profiling is not necessary.
Scientist-Led Study Design
INDIGO works with customers to align the assay with the actual biological question.
Gene Expression Studies in Relevant Cell Systems
INDIGO’s Gene Expression Services can support mechanistic follow-up in cell systems selected to match the biological question.
For some studies, that may include hepatocyte models when the focus is metabolism, CYP biology, or liver-relevant response. For others, the right model may be a non-hepatocyte system better suited to inflammatory, immune, or pathway-specific biology.
The goal is to generate targeted expression data in the system most relevant to the question being asked.
Common Applications
- Pathway confirmation after a functional assay
- Hepatocyte response assessment
- CYP- or metabolism-related follow-up
- Inflammation- or stress-response studies
- Mechanistic toxicology follow-up
- Targeted comparison of compounds, concentrations, or treatment conditions
Built for Scientists Who Have a Biological Question
Affordable Gene Expression Solutions
Reliable and cost-effective, we offer Gene Expression testing services designed to provide the answers you need.
Fast Screening & Data Delivery
Access crucial information on gene expression quickly with INDIGO’s gene expression services.
Detailed Reports & Available Technical Support
Our team delivers high-quality data analysis and reviews, putting INDIGO’s many years of experience at your service.
Get Started in Three Simple Steps
Design your next study rapidly and confidently with our expert team.
Step 1: Request a Quote in One Click
Fill out a Request a Quote form and tell us more about your study and objectives.
Step 2: Design Your Service Study with Our Scientists
Receive your quote and a custom draft of your Service Work Order.
Review and adjust to fit your needs.
Step 3: Send Your Samples and Get Your Results
Provide your samples or compounds, and we will do the rest.
Receive a complete data package and clear study reports in record time!
Citations
Cranberry contains high levels of nutrients and bioactive molecules that have health‐promoting properties. The purpose of the present studies was to determine if cranberry extracts (CEs) contain phytochemicals that exert anti‐inflammatory effects. The human monocytic cell line THP‐1 was treated with two CEs (CE and 90MX) and subsequently challenged with Lipopolysaccharides (LPS). Tumor necrosis factor α (TNF α) expression was decreased in the CE‐treated cells, indicative of an anti‐inflammatory effect. Gene expression microarrays identified several immune‐related genes that were responsive to CEs including interferon‐induced protein with tetratricopeptide repeats 1 and 3 (IFIT 1 and 3), macrophage scavenger receptor 1 (MSR1) and colony‐stimulating factor 2 (CSF2). In addition, in the CE‐treated cells, metallothionein 1F and other metal‐responsive genes were induced. Taken together, this data indicates that CEs contain bioactive components that have anti‐inflammatory effects and may protect cells from oxidative damage.
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