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Nuclear Receptor & In Vitro Toxicology Solutions™

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  • ABOUT
    • About INDIGO
    • Why INDIGO
    • Key Personnel
      • Board of Directors & Advisors
      • Management
    • Employment
    • INDIGO Press Releases
    • INDIGO in the News
  • ASSAYS
    • By Receptor
    • By Disease State
      • Overview
      • Anemia & Kidney Disease
      • Autoimmune Disease & Inflammation
      • Cancer
      • Cardiovascular Disease
      • Diabetes
      • Endocrinology
      • NAFLD/NASH
      • Obesity
    • Toxicology Solutions
      • In Vitro Toxicology Platform
      • Gene Expression
      • MDR1 / Human P-Glycoprotein
      • Discovery Toxicology
      • Environmental Monitoring
    • INDIGlo Luciferase Detection Reagent
    • Live Cell Multiplex
    • Ortholog Assays
    • Custom Assay Development
  • TECHNOLOGY
    • Nuclear Receptor Overview
    • Assay Kit Platform & Formats
    • Nuclear Receptor Profiling & Panels
    • Environmental Testing Solutions
    • Growth Factor Receptors
    • upcyte® Hepatocytes
    • FAQ
  • RESOURCES
    • Technical Manuals
    • Safety Data Sheets
    • Scientific Whitepapers from INDIGO
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    • New Research Publications
    • Nuclear Receptor Resource
  • CONTACT US
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Environmental Testing Solutions from INDIGO

INDIGO’s effects-based bioassay solutions compliment traditional analytical chemistry approaches for the examination of water quality and can help protect human and environmental health.

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Are Traditional Water Quality Methods Enough?

Traditional techniques rely on analyses and data for individual contaminants. Real world exposure generally occurs as mixtures of different chemical compounds. According to the EPA this presents risks posed to humans and the environment from:

  • chemicals without toxicity information
  • the presence and concentrations of other compounds
  • chemicals that work together to increase the toxic potential

To understand the risk posed by complex samples cell-based assay are needed to characterize cumulative effects on humans and other organisms.

Cell-Based Assays: The Next Wave in Evaluating Water Quality

Cell-based reporter assays such as those provided by INDIGO Biosciences screen for total bioactivity for a specific pathway of importance. They can detect the toxicity of unknown chemicals and can account for the cumulative effects simplifying the issues posed by complex mixtures in analytical methods. INDIGO has an extensive list of cellular bioassays that are predictive of cellular toxicity pathways including endocrine disruption, altered xenobiotic metabolism and adaptive stress responses.

INDIGO's assays can detect the cumulative effect of bioactive compounds in extracted environmental matrices and provide important biological context. They are:

  • All-Inclusive
  • Sensitive
  • Cost Effective
  • Reproducible
  • and Easy to Perform

Learn more about INDIGO Biosciences’ Assay Kit Platforms & Formats

INDIGO has an extensive list of bioassay kits for receptors important in Environmental Monitoring for contaminant detection and quantification in samples which include:

Endocrine Disruption

  • AR (NR3C4)
  • ERα (NR3A1)
  • ERβ (NR3A2)
  • GR (NR3C1)
  • PGR (NR3C3)
  • TRα (NR1A1)

Toxicity and Inflammation

  • NF-kB
  • Nrf2

Xenobiotic Metabolism

  • AhR
  • CAR-2 (NR1I3i2)
  • CAR-3 (NR1I3i3)
  • FXR (NR1H4)
  • PXR (NR1I2)
  • VDR (NR1I1)

Lipid and Energy Metabolism

  • LXRβ (NR1H2)
  • PPARγ (NR1C3)
  • RXRα (NR2B1)
  • TRβ (NR1A2)

Basal metabolism

  • LXRα (NR1H3)
  • MR (NR3C2)
  • RARγ (NR1B3)
  • RXRβ (NR2B2)
  • RXRγ (NR2B3)

Our receptor specific assays are cell-based reporter assay systems. They feature engineered receptor-specific reporter cells prepared using our unique CryoMite™ process. Once thawed, reporter cells are ready for immediate use. Test compounds can be screened for agonist or antagonist activities against receptors.

INDIGO Biosciences works closely with clients to provide the appropriate reporter specific assays for their water testing needs. Our technology generates clear single receptor or full-panel screening results. Employing a luminescence-based method and our proprietary CryoMite™ preservation process, INDIGO kits provide reproducible results lot-to-lot.

Learn more about INDIGO Biosciences’ Assay Kit Platforms & Formats
INDIGO is a leading provider of cell-based reporter assay solutions, recognized for our focus on providing a superior combination of expertise, service, and support. Organizations across the globe leverage our industry-leading platforms, knowledgeable people, and proprietary science for single receptor or full-panel screenings. Committed to ensuring the results we provide inform assured next steps, our team goes the extra mile by offering complimentary study consultation and design. Service assays include a positive control reference compound and ‘vehicle’ control for every experiment. At the completion of the study a formal study report including helpful graphics, summaries, and insights, as well as all data files are provided to the client. Our scientists are also available to provide a comprehensive review of the results with you once your service study is complete. To receive a quote for your proposed study, complete & submit the online "Request a Quote" form or contact an INDIGO Customer Service Representative to discuss your desired study parameters.

Learn more in this webinar presented by INDIGO C.S.O. Jack Vanden Heuvel

Learn more about Environmental Toxicology in our Blog

Environmental papers utilizing INDIGO kit and services

INDIGO Biosciences - The right partner for all your discovery and toxicology needs.
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