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  • PRODUCTS
    • Assay Kit Platform & Formats
    • All Assays
    • Growth Factor Assays
    • Toxicology Assays
      • In Vitro Hepatotoxicity Assay Kit
      • Gene Expression Profiling Assay Kit
      • P-gp/MDR1 Drug Interaction Assay Kit
    • Environmental Monitoring Assays
    • Ortholog Receptor Assays
    • INDIGlo Luciferase Detection Reagent
    • Live Cell Multiplex
  • SERVICES
    • Reporter Assay Services
    • Nuclear Hormone Receptor Profiling
    • Environmental Monitoring Services
    • Gene Expression Profiling Services
    • In Vitro Hepatotoxicity Screening Services
    • Custom Assay Development
  • APPLICATIONS
    • Drug Discovery
    • Discovery Toxicology
    • Disease States
      • Overview
      • Anemia & Kidney Disease
      • Autoimmune Disease & Inflammation
      • Cancer
      • Cardiovascular Disease
      • Diabetes
      • Endocrinology
      • NAFLD/NASH
      • Obesity
    • Environmental Monitoring
  • RESOURCES
    • Nuclear Receptor Overview
    • Webinars and Publications
      • New Research Publications
      • Webinars from INDIGO
      • Scientific Whitepapers from INDIGO
      • Scientific Posters from INDIGO
      • BLOG
    • Product Literature
      • INDIGO Technical Manuals
      • Product SDS
      • upcyte® Hepatocytes
    • FAQ
  • ABOUT
    • About INDIGO
    • Why INDIGO
    • Key Personnel
      • Board of Directors & Advisors
      • Management
    • Employment
    • INDIGO Press Releases
    • INDIGO in the News
  • CONTACT
    • Contact INDIGO
    • Request a Quote
    • Ordering & Distributors
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Reporter Assays in Drug Discovery

Modern drug discovery involves the identification of screening hits, medicinal chemistry, and optimization of those hits to increase the affinity, selectivity, efficacy/potency, metabolic stability, and bioavailability. INDIGO’s kits and services are ideal for drug discovery because they provide a convenient way to examine a compound for its ability to regulate nuclear receptor activity in agonist, inverse-agonist, or antagonist mode.

Using our robust cell-based reporter assays and nuclear receptor expertise allows you to better identify and prioritize drug leads. INDIGO’s research lab can aid in the identification of targets of interest and help your research with complimentary study consults and design. The INDIGO team can also aid in reducing the number of viable leads with high-throughput screening of compounds for efficacy and potency. Our scientists aim to get you to the next phase of discovery faster and prevent unnecessary steps backward by providing the most comprehensive data for your investment with fast turnaround times.

Whether you are just beginning the drug discovery process, or have narrowed down viable leads using INDIGO’s services or through your own effort, INDIGO’s cell-based assays allow you to examine a compounds efficacy and potency in cells, in your own lab. Our cell-based reporter assays are designed to quantify nuclear receptor activity with clear, reproducible data lot-to-lot. This allows for the prioritization of leads by learning the efficacy of a compound in vitro, as well as to establish the EC50/IC50 values and potential recommended dosing levels. This can be done with human receptors as well as those of orthologs to decide which animal model would be best for in vivo animal trials.

More information on INDIGO’s Assay Kit Platform & Formats

INDIGO’s research services and assay kits provide a convenient way to examine your compound’s ability to regulate nuclear receptor activity in robust, cell-based reporter assays.

View the full portfolio of INDIGO’s cell-based assays

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