ABSTRACT Small molecule agonism of PPARα represents a promising new avenue for the development of non-invasive treatments for oculovascular diseases like diabetic retinopathy and age-related macular degeneration. Herein we report initial structure–activity relationships for the newly identified quinoline-based PPARα agonist, Y-0452. Preliminary computational studies led to the hypothesis that carboxylic acid transposition and deconstruction ofRead More

ABSTRACT The invention disclosed herein is directed to compounds of Formula I and pharmaceutically acceptable salts thereof, which are useful in the treatment of prostate, breast, colon, pancreatic, human chronic lymphocytic leukemia, acute or chronic myeloid leukemia, melanoma, and other cancers. The invention also includes pharmaceutical compositions comprising a therapeutically effective amount of compound ofRead More

View Full Size Research conducted by: Samar W. Maalouf (1); John P. Vanden Heuvel (1,2); Bruce Sherf (1); &Zahidur R. Abedin (3) (1) INDIGO Biosciences, Inc., 1981 Pine Hall Road, State College, PA, USA (2) Department of Veterinary Medicine and Biomedical Sciences, 122 ASI, Penn State University, University Park, PA, USA (3) PrimBio Research Institute,Read More

View Full Size Research conducted by: Bruce Sherf (1); Samar W. Maalouf (1); Kaarthik John (1); Zahidur R. Abedin (1); & John P. Vanden Heuvel (1,3) (1) INDIGO Biosciences, Inc., 1981 Pine Hall Road, State College, PA, USA (2) PrimBio Research Institute, LLC, 665 Stockton Drive, STE 2001, Exton,  PA, USA (Website) (3) Department ofRead More

View Full Size Research conducted by: John P. Vanden Heuvel (1,2); Samar Maalouf (1); Megan V. Granda (2); & Bruce Sherf (1) (1) INDIGO Biosciences, Inc., 1981 Pine Hall Road, State College, PA, USA (2) Department of Veterinary Medicine and Biomedical Sciences, 122 ASI, Penn State University, University Park, PA 16802, USA Date of Publication:Read More

“Scientists have shown that a protein can help deliver many of the benefits associated with endurance exercise.” “If you’ve ever wondered how strenuous exercise translates into better endurance, researchers at the Salk Institute may have your answer. In a study published in the journal Cell Reports, scientists in Ronald Evans’ lab have shown that the protein ERRγ (ERR gamma)Read More

ABSTRACT Triphenyl phosphate (TPHP) is an unsubstituted aryl phosphate ester used as a flame retardant and plasticizer within the United States. Using zebrafish as a model, the objectives of this study were to rely on (1) mRNA-sequencing to uncover pathways disrupted following embryonic TPHP exposure and (2) high-content screening to identify nuclear receptor ligands thatRead More

ABSTRACT In 2016, as part of the Reproducibility Project: Cancer Biology, we published a Registered Report (Vanden Heuvel et al., 2016), that described how we intended to replicate selected experiments from the paper ‘Systematic identification of genomic markers of drug sensitivity in cancer cells’ (Garnett et al., 2012). Here we report the results. We foundRead More

ABSTRACT Psoriasis affects 3% of the population worldwide, and there is no known cure. Psoriasis is associated with an increased risk of psoriatic arthritis, lymphomas, cardiovascular disease, and Crohn’s disease. Psoriasis treatments today include steroid and vitamin D3 cream, ultraviolet light, and immune system suppressing medications such as methotrexate. The T cells responsible for psoriasisRead More

ABSTRACT Experimental data demonstrate a mode of action (MOA) for liver tumors in male rats and mice treated with sedaxane that starts with activation of CAR, followed by altered expression of CAR-responsive genes, increased cell proliferation, and eventually clonal expansion of preneoplastic cells, leading to the development of altered foci and tumors. This MOA isRead More