ABSTRACT
The present application provides novel tetrahydro – isohumulone ( THIAA ) derivatives and substantially enantiomerically pure compositions and pharmaceutical formulations thereof . The application further provides methods of using the disclosed compounds and compositions to activate PPARy , inhibit inflammation , and treat conditions associated with inflammation and conditions responsive to PPARY modulation such as diabetes.
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Patent Application Number: 15/823,448
Filing Date: 27 November 2018
Publication Date: 18 October 2018
Inventor information: Veera Konda (Bellevue, WA, US); Jan Urban (Port Orchard, WA, US); Anuradha Desai (Bellevue, WA, US); Clinton J. Dahlberg (Port Orchard, WA, US); & Brian J. Carroll (Gig Harbor, WA, US)