Product Search Reset all × Expression Profiling of Clinically Relevant CYPs × search: fxr × 1 product found × Target Receptor— Expression Profiling of Clinically Relevant CYPs Expression Profiling of Clinically Relevant CYPs (1) Farnesoid X Receptor (FXR, NR1H4) (5) G Protein-Coupled Bile Acid Receptor (TGR5; GPBAR1) (1) Species Human (1) Assay Mode Gene Expression (1) in vitro Hepatotox (1) Show (1) Cancel Reset all × Expression Profiling of Clinically Relevant CYPs × search: fxr × Showing the single result Default sorting Sort by popularity Sort by latest Sort by price: low to high Sort by price: high to low Expression Profiling of Clinically Relevant CYPs Assay KitSpeciesHumanThis Expression Profiling of Clinically Relevant CYPs assay kit contains optimized reagents for the culturing and treatment of upcyte® hepatocytes to assess drug-induced changes in CYP3A4, CYP1A1, CYP2B6, CYP2C8, CYP2C9, CYP2C19, and CYP2E1. The kit provides two aliquots of upcyte® hepatocytes, two cell culture-ready assay plates, optimized Cell Culture Medium for use in all steps of the assay procedure, and three reference compounds (rifampicin, β-naphthoflavone, and CDCA) that activate one or more of the primary xenobiotic-sensing receptors: PXR, CAR, AhR, and FXR. Upon activation, these nuclear receptors modulate the expression of the CYP genes. Also included are seven sets of validated qPCR primers for quantifying drug-induced changes in the expression of CYP3A4, CYP1A1, CYP2B6, CYP2C8, CYP2C9, CYP2C19, and CYP2E1, as well as primers for ACTB. Please note: This kit does not include reagents or protocols for cell lysis, RNA isolation, cDNA preparation, or qPCR assays.