Receptors for Cardiovascular Disease Treatment Research
Nuclear receptors and other receptors are critical regulators of metabolism, inflammation, and regeneration. Understanding the mechanisms underlying the involvement of nuclear receptors, as well as other receptors in the pathogenesis of cardiovascular disease and atherosclerosis may offer targets for the development of new treatments.
Specific receptors that are implicated as promising therapeutic targets for drug discovery in cardiovascular disease and atherosclerosis research include:
- ERα (NR3A1)
- ERβ (NR3A2)
- ERRγ (NR3B3)
- LXRα (NR1H3)
- LXRβ (NR1H2)
- PPARα (NR1C1)
- RORα (NR1F1)
- TEAD/YAP (Hippo Pathway)
Our receptor specific assays are cell-based reporter assay systems. They feature engineered receptor-specific reporter cells prepared using our unique CryoMite™ process. Once thawed, reporter cells are ready for immediate use. Test compounds can be screened for agonist or antagonist activities against receptors.
INDIGO Biosciences works closely with clients to provide the appropriate reporter specific assays for their cardiovascular disease research. To empower confident decision-making throughout the discovery process, our technology generates clear single receptor or full-panel screening results. Employing a luminescence-based method and our proprietary CryoMite™ preservation process, we provide reproducible results lot-to-lot about the efficacy, potency, and selectivity of your compounds, plus comprehensive lab reports that include helpful graphics, summaries, and insights.
Cardiovascular disease or heart disease describes a range of conditions that affect the cardiovascular system including blood vessel diseases, arrhythmias, and cardiomyopathy. Causes including diabetes, smoking, stress, obesity, and an existing family history have been associated with cardiovascular disease. A major indicator of developing cardiovascular disease is atherosclerosis. Atherosclerosis happens when plaque builds up in and on the walls of the arteries. This buildup of plaque narrows the arteries, making it hard for blood to flow.
Signs and symptoms vary for different types of cardiovascular disease, but often include fatigue, high blood pressure, chest pain, and shortness of breath. Complications associated with cardiovascular disease can lead to aneurysms, cardiac arrest, heart failure, stroke, and death. In fact, cardiovascular diseases are regularly among the top global causes of death reported by the World Health Organization. Diagnosis of cardiovascular disease typically involves an electrocardiography, echocardiography, or stress testing to screen for the disease.
Initial treatment of cardiovascular disease largely focuses on diet, lifestyle changes, as well as medication. If these treatments are not enough, surgical intervention may be required.