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Mechanistic Toxicology & Functional Screening
Transforming Early Safety Assessment with Human-Relevant, Mechanistic, In Vitro Tools, New Approach Methods (NAMs)
At INDIGO Biosciences, we provide specialized preclinical safety and toxicology services that emphasize mechanistic insight, human relevance, high throughput, and early decision-making. Our platform supports your traditional ADME/pharmacokinetics or in vivo safety pharmacology by delivering functional, cell-based assays, human hepatocyte-based liver safety testing, metabolic liability screens, and off-target receptor profiling all tailored to support discovery and lead-optimization workflows under modern New Approach Methods (NAMs).
We help Clients
- Identify endocrine, metabolic, and receptor-mediated toxicity liabilities early
- Evaluate hepatotoxicity and drug–drug interaction (DDI) risk using human-relevant liver models
- Screen for off-target pharmacology and unintended pathway activation
- Prioritize safer, more viable chemical series before committing to costly in vivo or clinical programs
- Test for chemical clearance
- SAR optimization
Why Choose INDIGO’s Mechanistic Toxicology & Functional Screening Services?
Early Risk Assessment
By integrating mechanistic, metabolic, and toxicity screening at an early stage, you can identify red flags before committing to expensive in vivo or clinical studies.
Human-relevant, mechanistic data
Our assays use human cells (or human-relevant models) to generate functional responses; this improves translatability and reduces reliance on animal models.
Comprehensive deliverables
Full reports, raw data, GraphPad files, and expert interpretation support informed decision-making.
Get your Studies Started in Three Simple Steps
Design your next Mechanistic Toxicology & Functional Screening service rapidly and confidently with our expert team.
Step 1: Contact our scientific team to schedule a consultation and define your study design
Step 2: Design Your Service Study with Our Scientists
Receive your quote and a custom draft of your Service Work Order.
Review and adjust to fit your needs.
Step 3: Send Your Samples and Get Your Results
Provide your samples or compounds, and we will do the rest.
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