Anemia & Kidney Disease

INDIGO’s assay kits and services can provide valuable information for your anemia & kidney disease research. Whether you are interested in a single-receptor assay or a full-panel study, we can help you obtain the data you need quickly.


Receptors for Anemia & Kidney Disease Research

Various receptors are targets for anemia and chronic kidney disease research due to their involvement in the signaling pathways for metabolism, immune response, and inflammation. Understanding the mechanisms underlying the involvement of various receptors in the pathogenesis of certain anemias and chronic kidney disease, as well as the complications and comorbidities that result from it may offer targets for the development of new treatments.


Indigo Assays for Anemia & Kidney Disease Research

INDIGO Biosciences offers assays for receptors that are implicated as promising therapeutic targets for drug discovery in anemia and kidney disease:


Anemia is a condition in which the blood has a low number of red blood cells. This results in reduced oxygen flow to the body. Anemia is the most common blood condition in the United Stated affecting almost 6% of the population. There are three main causes for anemia including, blood loss, lack of red blood cell production, and high rates of red blood cell apoptosis.

Symptoms may include fatigue, cold hands and feet, pale or yellow skin, shortness of breath, lightheadedness, or a fast heartbeat. Comorbidities of anemia are hypertension, hypothyroidism, cancer, cardiovascular disease, rheumatologic disease, and chronic kidney disease.

Kidney Disease

Chronic kidney disease (chronic renal disease) includes a variety of conditions that damage the kidneys and decrease their functioning. As kidney disease progresses, less waste gets filtered out, and it can build to high levels. There is an increased risk for developing chronic kidney disease for those with a family history of kidney disease, as well as those with the comorbidities diabetes, high blood pressure, and cardiovascular disease. More than 37 million people in the United States may have chronic kidney disease.

There typically are no symptoms in the early stages of chronic kidney disease, but as kidney damage progresses, signs and symptoms can include, nausea, vomiting, loss of appetite, fatigue and weakness, sleep problems, more frequent urination, swelling of feet and ankles, persistent itching, chest pain, and shortness of breath. Complications of chronic kidney disease include fluid retention, cardiovascular disease, anemia, decreased sex drive, damage to the CNS, decreased immune response, pericarditis, and end-stage kidney disease. Chronic kidney disease can be diagnosed using a blood test to measure the glomerular filtration rate or a urine test to check for albumin. Imaging tests, and kidney biopsy can also be performed to understand the type of kidney disease and how much damage has occurred to recommend treatment.

Once damage to the kidney has occurred it is permanent. Treatment of chronic kidney disease largely depends on the underlying cause, but usually consists of measures to help control signs and symptoms and slow the progression of the disease. If the disease progresses to end-stage kidney disease when less than 15% of the kidney is functioning, treatments to maintain health include dialysis and kidney transplantation.

Related Products and Services

A scientist dispenses a sample into a microcentrifuge tube within a BCL2 cabinet.

Drug Discovery Assay Kits

Get fast, clear, reproducible results from INDIGO’s all-inclusive reporter assay kits. No cell culture required!

Automatic pipette dispensing into a 96 well plate

Reporter Assay Services

Rapidly gain a clear overview of chemicals, pharmaceutical compounds, or environmental samples on key biological receptors.

Loading test samples into a multiwell reaction plate

Custom Assay Development

Contact our team of specialists and design custom assays tailored to your needs.

Related Information

Nuclear Receptors and Their Classifications


How Nuclear Receptor Profiling Can Determine the Fate of Your Compounds


How to Develop Testing Strategy for EDCs in Water Resources


Profiling Drug Activity of Human and Ortholog Xenobiotic-Sensing Receptors: PXR, CAR, AhR, and FXR - INDIGO Biosciences


Regulation of Steatosis in upcyte® Hepatocytes by Nuclear Receptor Agnostics


Correlation Between Cytochrome P450 Inducers and Nuclear Receptor Activation - a Screening Approach - INDIGO Biosciences


Human CYP2B6 Produces Oxylipins from Polyunsaturated Fatty Acids and Reduces Diet-Induced Obesity

Disruption of the Tumor Suppressor-Like Activity of Aryl Hydrocarbon Receptor by Arsenic in Epithelial Cells and Human Lung Cancer

Effects-Based Monitoring of Bioactive Compounds Associated with Municipal Wastewater Treatment Plant Effluent Discharge to the South Platte River, Colorado, USA

What Our Customers Say

"They’re one of the best suppliers that we’ve worked with by far. They were very communicative as far as getting us the reagents we needed quickly."


Principal Scientist

"The overall experience went smoothly, and I got valuable data that helped me advance several molecules through the discovery pipeline."


Associate Director

"The fact that they do have this comprehensive panel…essentially you can pick and choose which of the members of the panel you want to run."



Interested to know more about nuclear receptor assays?

Questions/Request a Quote