ADME Testing and Safety Pharmacology: Ensuring Drug Efficacy and Safety

We test a wide range of small molecules, biologics, and peptides in our ADME assays.

CYP450 enzymes are responsible for the metabolism of many drugs. Testing for inhibition or induction can predict potential drug-drug interactions.

Yes, we can design off-target panels tailored to your specific needs based on receptor types and pathways relevant to your compounds.

Treatment concentrations are prepared at INDIGO using serial dilutions in fixed increments; the starting concentration and increment of dilution is specified by the customer via our Study Work Order sheet that accompanies all screening studies. For accurate determination of EC50 and/or IC50 values, we recommend at minimum spanning a 5,000-fold concentration range over 8 doses. This strategy requires a 3.33-fold or 4-fold increment of serial dilution. The minimum doses recommended for EC50 and/or IC50 value is 7 test concentrations.

We pride ourselves on quick delivery, with most studies completed within 2–3 weeks, depending on complexity.

Upon completion of your study, you will receive a detailed study report (PDF format) including all assay methods and validation, the raw data and calculations of your study (Excel format), and graphing files of all data (GraphPad Prism format). In addition, you are always welcome to contact INDIGO’s team for assistance in interpretation of your data.