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  • HOME
  • ABOUT
    • About
    • Why INDIGO
    • Key Personnel
      • Board of Directors & Advisors
      • Management
  • PRODUCTS
    • Assays
    • Ortholog Assays
    • Growth Factor Receptors
    • In Vitro Toxicology Platform
    • MDR1 / Human P-Glycoprotein
    • Gene Expression
    • NASH Nuclear Receptors For Research
    • Disease States
    • Live Cell Multiplex
    • Custom Assay Development
  • TECHNICAL
    • Nuclear Receptor Profiling & Panels
    • Assay Kit Platform & Formats
    • FAQ
    • Discovery Toxicology
    • upcyte® Hepatocytes
    • Technical Manuals & Product Listing
    • Safety Data Sheets
    • Product Policies
    • Terms & Conditions
    • Limited Use Disclosures
  • CONTACT US
    • Contact INDIGO
    • Request Information
    • Request a Quote
    • Employment
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  • RESOURCES
    • Blog
    • Nuclear Receptor Resource
    • Scientific Whitepapers from INDIGO
    • New Research Publications
    • Scientific Posters
    • INDIGO Press Releases
    • INDIGO in the News
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Liver Receptor Homolog-1 (LRH-1; NR5A2)

Assay available as Screening Service

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LRH-1 is a nuclear receptor that is an essential regulator of gene transcription, critical for early cellular development and imperative for the proper functions of the liver, pancreas, and intestines during the adult life. In the liver, LRH-1 regulates the expression of key genes involved in bile acid synthesis, cholesterol homeostasis and transport. Because of its decisive role in cell differentiation, LRH-1 is linked to multiple developmental pathways. LRH-1 activity is linked to breast and endometrial cancers as well as intestinal tumors and cancer of the pancreas.

This nuclear receptor assay system utilizes proprietary non-human mammalian cells engineered to provide high-level expression of a hybrid form of the Human Liver Receptor Homolog-1 (NR5A2), commonly called LRH-1. The N-terminal DNA binding domains (DBD) of the native LRH-1 has been substituted with that of the yeast GAL4-DBD. The reporter gene is beetle luciferase functionally linked to the GAL4 upstream activation sequence (UAS).

As is true in vivo, these reporter cells express LRH-1 that is constitutively active in the (putative) absence of ligand binding. A ligand binding event may diminish the constitutive activity of the receptor (an inverse-agonist response), or further elevates the already high constitutive activity of LRH-1 (an agonist response).

For more information on LRH-1, visit the Nuclear Receptor Resource.

Service Assays: Human

The primary application of INDIGO’s cell-based nuclear receptor assays are to quantitatively assess the bioactivity of a test compound as an agonist (activator) or antagonist (inhibition of an agonist response) of a given receptor. Service assays include a positive control reference compound and ‘vehicle’ control for every experiment. A formal study report and all data files are provided to the client upon completion of the study. To receive a quote for your proposed study, complete & submit the online “Request a Quote” form or contact an INDIGO Customer Service Representative to discuss your desired study parameters.

Dyslipidemia; Cancer; Steroidogenesis; Bile Acid and Xenobiotic; Metabolic Disease

Indigo Announces In Vitro Toxicology Platform

In vitro toxicology platform provides predictive model of liver toxicity.  Aims to reduce the high rates of drug­-induced liver damage State College, PA (May 4, 2016) INDIGO Biosciences, the recognized industry leader in nuclear receptor research, has completed development of an in vitro toxicology platform, meeting the demand for predictive liver toxicity models.  INDIGO’s inRead More

Posted in press | Tagged AhR, CAR, In Vitro Toxicology, LRH-1, LXR, Nrf2, PPAR, PXR | Comments Off on Indigo Announces In Vitro Toxicology Platform

INDIGO Now Offering LRH-1 Assay Systems

New Assay Critical to the Study of Diabetes, Pancreatic Cancer, and Metabolic Diseases  State College, PA (January 20, 2016) INDIGO Biosciences, the recognized industry leader in nuclear receptor research, has expanded its offerings to include liver homology receptor-1 (LRH-1) kits and services. LRH-1, also called NR5A2, is a nuclear receptor that is an essential regulatorRead More

Posted in press | Tagged LRH-1 | Comments Off on INDIGO Now Offering LRH-1 Assay Systems
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