Receptors For Diabetes Research
Nuclear receptors and other receptors are targets for diabetes research due to their involvement in the signaling pathway for carbohydrate metabolism, lipid metabolism, immunity, and inflammation. Understanding the mechanisms underlying the involvement of various receptors in the pathogenesis of diabetes mellitus, as well as the complications that result from the disease may oﬀer targets for the development of new treatments.
Specific receptors that are implicated as promising therapeutic targets for drug discovery in diabetes research include:
- GR (NR3C1)
- LXRα (NR1H3)
- LXRβ (NR1H2)
- PPARγ (NR1C3)
- RXRα (NR2B1)
- RXRβ (NR2B2)
- RXRγ (NR2B3)
Our receptor specific assays are cell-based reporter assay systems. They feature engineered receptor-specific reporter cells prepared using our unique CryoMite™ process. Once thawed, reporter cells are ready for immediate use. Test compounds can be screened for agonist or antagonist activities against receptors.
INDIGO Biosciences works closely with clients to provide the appropriate reporter specific assays for their diabetes research. To empower confident decision-making throughout the discovery process, our technology generates clear single receptor or full-panel screening results. Employing a luminescence-based method and our proprietary CryoMite™ preservation process, we provide reproducible results lot-to-lot about the efficacy, potency, and selectivity of your compounds, plus comprehensive lab reports that include helpful graphics, summaries, and insights.
Diabetes mellitus is a progressive metabolic disorder with diverse pathological manifestation in which blood glucose levels are elevated due to the bodies inability to maintain glucose homeostasis. It is estimated that more than 34 million people in the United States have diabetes, with one in five not knowing they have it. There are three main types of diabetes: type 1, type 2, and gestational diabetes. Type 1 diabetes is thought to be caused by an autoimmune response that stops the body from producing insulin. Type 2 diabetes occurs when the body either doesn't produce enough insulin, or it resists insulin. Of the two types, type 2 is the most prevalent with about 90-95% of the diabetic population being type 2. Gestational diabetes develops during pregnancy and typically ends when the baby is born but increases the risk of developing type 2 later in life.
Signs and symptoms of diabetes include increased thirst, frequent urination, extreme hunger, unexplained weight loss, fatigue, blurred vision, slow-healing sores, and presence of ketones in the urine. Complications associated with diabetes when left untreated can include Alzheimer's disease, cardiovascular disease, neuropathy, nephropathy, and retinopathy, as well as toe, foot, or leg amputation. There are multiple ways to test and determine if someone has diabetes including an A1C test, Random Plasma Glucose Test, Fasting Plasma Glucose (FPG), Oral Glucose Tolerance Test (OGTT), or keto test.
The exact cause of type 1 and type 2 diabetes is unknown, though both are thought to be caused by a combination of a genetic predisposition and environmental factors. While the exact environmental factors are also unknown, being overweight is strongly linked to the development of type 2. No cure for diabetes currently exists though treatments to manage the disease involve a combination of medications, exercise, diet, lifestyle changes, and insulin injections.