Receptors For Endocrine Research
Nuclear receptors are a critical part of endocrine functioning. Understanding the mechanisms underlying the involvement of nuclear receptors in the pathogenesis of endocrine disorders may oﬀer targets for the development of new treatments, as well as creating better treatments for correcting hormone imbalances caused by endocrine disorders.
Specific receptors that are implicated as promising therapeutic targets for drug discovery in endocrine research include:
Our receptor specific assays are cell-based reporter assay systems. They feature engineered receptor-specific reporter cells prepared using our unique CryoMite™ process. Once thawed, reporter cells are ready for immediate use. Test compounds can be screened for agonist or antagonist activities against receptors.
INDIGO Biosciences works closely with clients to provide the appropriate reporter specific assays for their endocrine research. To empower confident decision-making throughout the discovery process, our technology generates clear single receptor or full-panel screening results. Employing a luminescence-based method and our proprietary CryoMite™ preservation process, we provide reproducible results lot-to-lot about the efficacy, potency, and selectivity of your compounds, plus comprehensive lab reports that include helpful graphics, summaries, and insights.
Endocrinology is the study of the messenger system comprising feedback loops of hormones released by internal glands. Hormones are used to communicate between organs and tissues for physiological regulation of multiple functions including autonomic functions, circadian rhythm, development and reproduction, metabolism, mood, and stress response.
There are many common endocrine disorders that cause disruptions in the endocrine system including diabetes mellitus, acromegaly, Addison’s disease, Cushing’s syndrome, and hyperthyroidism. Treatments for endocrine disorders vary depending on the specific disorder, but often focus on correcting the hormone imbalance.
Another source of study in endocrine research is from chemicals both man-made and natural that are full agonist, partial agonist, or antagonist of the receptors that function in the endocrine system. Perturbation caused by these chemicals, sometimes referred to as Endocrine Disrupting Chemicals (EDCs) can range in their physiological effects from tumorigenesis to birth defects and other developmental disorders. Many of these chemicals are lipophilic and are known to bioaccumulate in tissues. For those interested in endocrine disrupting chemicals, learn more in this white paper from INDIGO Nuclear Receptors & Endocrine / Metabolic Disruption.