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  • PRODUCTS
    • Assay Kit Platform & Formats
    • Reporter Assays By Receptor
    • Growth Factor Assays
    • Toxicology Kits
      • In Vitro Hepatotoxicity Assay Kit & Screening Services
      • Assay Kits & Services for Gene Expression Profiling
      • Human P-Glycoprotein / MDR1 Drug Interaction Assay Kit & Screening Services
    • Environmental Monitoring Assays
    • Animal Model Assays
    • INDIGlo Luciferase Detection Reagent
    • Live Cell Multiplex
  • SERVICES
    • Reporter Assay Services
    • Nuclear Receptor Profiling & Panels
    • Custom Assay Development
    • Environmental Testing Assays
    • Toxicology in The Drug Discovery and Development Process
  • RESOURCES
    • Nuclear Receptor Overview
    • Disease State Targets
      • Overview
      • Anemia & Kidney Disease
      • Autoimmune Disease & Inflammation
      • Cancer
      • Cardiovascular Disease
      • Diabetes
      • Endocrinology
      • NAFLD/NASH
      • Obesity
    • Articles, Blogs, and Posters
      • New Research Publications
      • Scientific Whitepapers from INDIGO
      • Scientific Posters from INDIGO
      • BLOG
    • Product Literature
      • INDIGO Technical Manuals
      • Product Material Safety Data Sheets
      • upcyte® Hepatocytes
    • FAQ
  • ABOUT
    • About INDIGO
    • Why INDIGO
    • Key Personnel
      • Board of Directors & Advisors
      • Management
    • Employment
    • INDIGO Press Releases
    • INDIGO in the News
  • CONTACT US
    • Contact INDIGO
    • Request a Quote
    • Ordering & Distributors
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Receptors For Obesity Research

Nuclear receptors and other receptors are targets for obesity research due to their involvement in the signaling pathway for regulating metabolism, as well as energy and lipid homeostasis. Understanding the mechanisms underlying the involvement of various receptors in the pathogenesis of obesity, as well as the complications and comorbidities that result from it may offer targets for the development of new treatments.

  • Associated Receptors
  • Disease State Background

Specific receptors that are implicated as promising therapeutic targets for drug discovery in obesity research include:

  • ERβ (NR3A2)
  • GHR
  • GR (NR3C1)
  • PPARδ (NR1C2)
  • PPARγ (NR1C3)
  • TGFβR
  • TRα (NR1A1)
  • TRβ (NR1A2)

Our receptor specific assays are cell-based reporter assay systems. They feature engineered receptor-specific reporter cells prepared using our unique CryoMite™ process. Once thawed, reporter cells are ready for immediate use. Test compounds can be screened for agonist or antagonist activities against receptors.

INDIGO Biosciences works closely with clients to provide the appropriate reporter specific assays for their diabetes research. To empower confident decision-making throughout the discovery process, our technology generates clear single receptor or full-panel screening results. Employing a luminescence-based method and our proprietary CryoMite™ preservation process, we provide reproducible results lot-to-lot about the efficacy, potency, and selectivity of your compounds, plus comprehensive lab reports that include helpful graphics, summaries, and insights.

Learn more about INDIGO Biosciences’ Assay Kit Platforms & Formats

Obesity is defined as abnormal or excessive fat accumulation that presents a risk to health. A body mass index (BMI) over 30 is considered obese, though this is not always accurate as some athletes have high BMI’s due to a high level of muscle mass. Obesity is primarily caused by an imbalance between calories consumed and calories expended which can result from a combination of genetic and environmental factors. Environmental factors leading to obesity can include medical conditions, physical activity, dietary patterns, and medications.

The signs and symptoms of obesity are excessive body fat, shortness of breath, trouble sleeping, skin problems, fatigue, and pain. Long term risks of obesity include developing serious diseases and comorbidities including NAFLD/NASH, hypertension, dyslipidemia, type 2 diabetes mellitus, cardiovascular disease, stroke, gallbladder disease, sleep apnea, and certain types of cancer. Obesity is considered a serious global health problem due to its increasing prevalence and comorbidities.

 
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