Receptors For Autoimmune Disease and Inflammation Research

Nuclear receptors and other receptors are targets for autoimmune research due to their involvement in the signaling pathways for inflammation and immunity. Autoimmune diseases also cause damage to the endocrine system causing over or underproduction of certain hormones. This makes therapies that are full or partial agonists, or antagonists of nuclear hormone receptors involved in endocrine function important for managing perturbations caused by specific autoimmune diseases.

Associated Receptors
Disease State Background

Specific receptors that are implicated as promising therapeutic targets for drug discovery in autoimmune and inflammation research include:

Our receptor specific assays are cell-based reporter assay systems. They feature engineered receptor-specific reporter cells prepared using our unique CryoMite™ process. Once thawed, reporter cells are ready for immediate use. Test compounds can be screened for agonist or antagonist activities against receptors.

INDIGO Biosciences works closely with clients to provide the appropriate reporter specific assays for their autoimmune and inflammation research. To empower confident decision-making throughout the discovery process, our technology generates clear single receptor or full-panel screening results, making for more precise data and allowing better interpretation. Employing a luminescence-based method and our proprietary CryoMite™ preservation process, we provide reproducible results lot-to-lot about the efficacy, potency, and selectivity of your compounds, plus comprehensive lab reports that include helpful graphics, summaries, and insights.

Learn more about INDIGO Biosciences’ Assay Kit Platforms & Formats

A healthy immune system defends the body against disease and infection, but if the immune system malfunctions, it can mistakenly attack healthy cells, tissues, and organs. Collectively diseases that result from dysfunction of the immune system, whether from abnormally low activity or over activity, are called autoimmune disease. These attacks can affect any part of the body, weakening bodily function and even turn life-threatening. More than 23 million people in the United States have an autoimmune disease and there are more than 80 known types of autoimmune diseases including type 1 diabetes, rheumatoid arthritis, psoriasis, and multiple sclerosis.

Many autoimmune diseases have similar symptoms. One of the classic signs of an autoimmune disease is the redness, heat, pain, and swelling caused by inflammation. Though inflammation is critical for the body’s normal immune responses, chronic inflammation has been shown to cause tissue damage. For these reasons and others, avenues for autoimmune disease research include the role of inflammation associated with immune system response.

Treatments for autoimmune diseases vary depending on the disease, but mostly consist of ways to reduce symptoms and reduce the immune systems abnormal response. Currently, the cause for autoimmune diseases is unknown but, due to the rise of incidences of autoimmune disease, researchers suspect environmental factors play a role.