Cancer

INDIGO’s assay kits and services can provide valuable information for your cancer research. Whether you are interested in a single-receptor assay or a full-panel study, we can help you obtain the data you need quickly.

Cancer@2x

Nuclear Receptors for Cancer Research

Nuclear receptors have long been targets in oncology research and the role of dysregulated nuclear receptor mediated signaling pathways in tumorigenesis has been well documented in a variety of cancers. Small molecule drugs that modulate nuclear receptors have proven to be effective therapeutic targets, such as with antagonists of the androgen receptor (AR) in patients with prostate cancer or the estrogen receptor alpha (ERα) in patients with ERα positive breast cancer. Nuclear receptors also play critical roles in the signaling pathways for inflammation and immunity and these pathways have been widely implicated in oncogenesis and may be potent therapeutic avenue for new cancer treatments.

Growth Factor Receptors for Cancer Research

Growth factor receptors are important targets in oncology because mutations that lead to constitutive activation of these signal pathways result in the progression of various types of cancers. Overexpression of receptor tyrosine kinases (RTK), which include the epidermal growth factor receptor (EGFR) family and the vascular endothelial growth factor receptor (VEGFR) family, among others, have been found in many tumors. Mutations in serine/threonine-specific protein kinase receptors such as transforming growth factor-beta (TGFβR) have also been linked to growth of many tumors due to defects in the cellular growth inhibition response to TGFβ. As discovery research continues, growth factors and growth factor signaling pathways remain promising targets in the development of oncologic therapeutics.

INDIGO-Assay-Kit@2x

INDIGO Assays for Cancer Research

INDIGO Biosciences offers assays for receptors that are implicated as promising therapeutic targets for drug discovery in cancer treatment:

Related Products and Services

A scientist dispenses a sample into a microcentrifuge tube within a BCL2 cabinet.

Drug Discovery Assay Kits

Get fast, clear, reproducible results from INDIGO’s all-inclusive reporter assay kits. No cell culture required!

Automatic pipette dispensing into a 96 well plate

Reporter Assay Services

Rapidly gain a clear overview of chemicals, pharmaceutical compounds, or environmental samples on key biological receptors.

Loading test samples into a multiwell reaction plate

Custom Assay Development

Contact our team of specialists and design custom assays tailored to your needs.

Related Information

Nuclear Receptors and Their Classifications

Cell@2x

How Nuclear Receptor Profiling Can Determine the Fate of Your Compounds

Nuclear-Receptor@2x

How to Develop Testing Strategy for EDCs in Water Resources

Waters@2x

Profiling Drug Activity of Human and Ortholog Xenobiotic-Sensing Receptors: PXR, CAR, AhR, and FXR - INDIGO Biosciences

Profiling-Drug-Activity-of-Human-and-Ortholog-Xenobiotic-Sensing-Receptors_-PXR,-CAR,-AhR,-and-FXR---INDIGO-Biosciences

Regulation of Steatosis in upcyte® Hepatocytes by Nuclear Receptor Agnostics

Regulation-of-Steatosis-in-upcyte®-Hepatocytes-by-Nuclear-Receptor-Agnostics

Correlation Between Cytochrome P450 Inducers and Nuclear Receptor Activation - a Screening Approach - INDIGO Biosciences

Correlation-Between-Cytochrome-P450-Inducers-and-Nuclear-Receptor-Activation---a-Screening-Approach

Human CYP2B6 Produces Oxylipins from Polyunsaturated Fatty Acids and Reduces Diet-Induced Obesity

Disruption of the Tumor Suppressor-Like Activity of Aryl Hydrocarbon Receptor by Arsenic in Epithelial Cells and Human Lung Cancer

Effects-Based Monitoring of Bioactive Compounds Associated with Municipal Wastewater Treatment Plant Effluent Discharge to the South Platte River, Colorado, USA

What Our Customers Say

"The overall experience went smoothly, and I got valuable data that helped me advance several molecules through the discovery pipeline."

Olivia

Associate Director

"I feel like they prioritize us just as much as we prioritize getting the data, which is very nice."

Mark

Principal Scientist

"The fact that they do have this comprehensive panel…essentially you can pick and choose which of the members of the panel you want to run."

Linda

Scientist

Interested to know more about nuclear receptor assays?

Questions/Request a Quote